{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:32Z","timestamp":1790188352488,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gingival enlargement is a side effect of several different medication, including immunosuppressants, anticonvulsants, and calcium channel blockers. It is an inflammatory response that starts when plaque and calculus build up on the tooth surface. The most prevalent long-term neurological condition affecting people is epilepsy. In affluent nations, the prevalence of epilepsy is ~ 1%, whereas in less developed countries, it may &amp;gt;2%. The preferred medication for the condition, phenytoin, has major side effects include gingival enlargement. In addition to being visually disfiguring, this enlargement frequently affects speech, chewing and eating. Furthermore, those with poor dental hygiene, causes disabilities with motor coordination and muscular limitations leading to mental disability and physical impairments are more prone to periodontal disease. This article enlightened the mechanism of drug induced gingival enlargement clinically, microbiologically, and surgically.<\/jats:p>","DOI":"10.1093\/jscr\/rjae304","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:24:01Z","timestamp":1716942241000},"source":"Crossref","is-referenced-by-count":7,"title":["Drug induced gingival enlargement - phenytoin: an overview and case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Nipun","family":"Dhalla","sequence":"first","affiliation":[{"name":"Department of Periodontology, Manav Rachna Dental College, SDS, MRIIRS , Q Block, Faridabad 121001, Haryana , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipika","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manav Rachna Dental College, SDS, MRIIRS , Q Block, Faridabad 121001, Haryana , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Palwankar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manav Rachna Dental College, SDS, MRIIRS , Q Block, Faridabad 121001, Haryana , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"2024052900235120500_ref1","article-title":"Refining the mechanism of drug-influenced gingival enlargement and its management","volume":"14","author":"Sabarudin","year":"2022","journal-title":"Cureus"},{"key":"2024052900235120500_ref2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2174\/1874210601711010420","article-title":"On the cellular and molecular mechanisms of drug-induced gingival overgrowth","volume":"11","author":"Ramirez","year":"2017","journal-title":"Open Dent J"},{"key":"2024052900235120500_ref3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1601-0825.1998.tb00269.x","article-title":"Medication induced gingival overgrowth","volume":"4","author":"Marshall","year":"1998","journal-title":"Oral Dis"},{"key":"2024052900235120500_ref4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4103\/0972-124X.201693","article-title":"Management of phenytoin-induced gingival enlargement in a patient with antiphospholipid antibody syndrome: a rare case report","volume":"20","author":"Urolagin","year":"2016","journal-title":"J Indian Soc Periodontol"},{"key":"2024052900235120500_ref5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1528-1157.1993.tb00433.x","article-title":"Comission on epidemiology and prognosis, international league against epilepsy","volume":"34","author":"Guidelines for epidemiologic studies on epilepsy","year":"1993","journal-title":"Epilepsia"},{"key":"2024052900235120500_ref6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jnnp.61.5.433","article-title":"Epidemiology of the epilepsies","volume":"6","author":"Sander","year":"1996","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"2024052900235120500_ref7","first-page":"130","article-title":"Clinical management of phenytoin-induced gingival overgrowth in handicapped children","volume":"3","author":"Arnold","year":"1981","journal-title":"Pediatr Dent"},{"key":"2024052900235120500_ref8","first-page":"497850","article-title":"Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features","volume":"2011","author":"Correa","year":"2011","journal-title":"ISRN Dent"},{"key":"2024052900235120500_ref9","volume-title":"Drug-Induced Gingival Overgrowth","author":"Tungare","year":"2024"},{"key":"2024052900235120500_ref10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/S1676-26492007000200009","article-title":"Drug-induced gingival enlargement - part II. 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