{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:46:41Z","timestamp":1790282801433,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary intracranial melanocytoma is an uncommon benign pigmented tumor arising from leptomeningeal melanocytes. Neuroimaging characteristics of central nervous system melanocytoma are distinct from similarly presenting intracranial neoplasms and can aid in diagnosis prior to histopathological examination. In rare cases, there may be more than one lesion present. We report a case of a 19-year-old woman presenting with progressively worsening headaches, nausea, emesis, and generalized weakness of 2\u00a0months. Imaging revealed tumors in the parietal and ipsilateral medial temporal lobe. The patient underwent gross total resection of the parietal lesion which histopathological assessment revealed to be primary intracranial meningeal melanocytoma. This case highlights the utility of specific imaging criteria such as diffusely increased T1 signal without enhancement in the initial diagnostic evaluation of intracranial melanocytoma. We also describe the clinical characteristics, management strategy, and histopathological features of a rare case of a patient with multiple primary intracranial melanocytoma lesions.<\/jats:p>","DOI":"10.1093\/jscr\/rjae332","type":"journal-article","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T19:33:05Z","timestamp":1716147185000},"source":"Crossref","is-referenced-by-count":1,"title":["Intracranial meningeal melanocytoma: a case report and literature review"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-0323","authenticated-orcid":false,"given":"Renuka","family":"Chintapalli","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Addenbrooke's Hospital , Hills Rd, Cambridge CB20QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"2024051919325649500_ref1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/00000478-199907000-00001","article-title":"Primary melanocytic neoplasms of the central nervous systems","volume":"23","author":"Brat","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"2024051919325649500_ref2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1477-7819-10-135","article-title":"Primary meningeal melanocytoma of the anterior cranial fossa: a case report and review of the literature","volume":"3","author":"Lin","year":"2012","journal-title":"World J Surg Oncol"},{"key":"2024051919325649500_ref3","first-page":"619","article-title":"Intracranial meningeal melanocytoma associated with ipsilateral nevus of Ota","volume":"96","author":"Piercecchi-Marti","year":"2002","journal-title":"Case report J Neurosurg"},{"key":"2024051919325649500_ref4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/1523-1747.ep12260111","article-title":"The distribution of melanocytes in the leptomeninges of the human brain","volume":"82","author":"Goldgeier","year":"1984","journal-title":"J Invest Dermatol"},{"key":"2024051919325649500_ref5","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/1097-0142(197211)30:5<1286::AID-CNCR2820300522>3.0.CO;2-V","article-title":"Meningeal melanocytoma (\u201cmelanotic meningioma\u201d). Its melanocytic origin as revealed by electron microscopy","volume":"30","author":"Limas","year":"1972","journal-title":"Cancer"},{"key":"2024051919325649500_ref6","doi-asserted-by":"crossref","first-page":"789256","DOI":"10.3389\/fsurg.2022.789256","article-title":"Malignant transformation and metastatic spread of dumbbell-shaped meningeal melanocytoma of the cervical spine: a case report and literature review","volume":"9","author":"Deng","year":"2022","journal-title":"Front Surg"},{"key":"2024051919325649500_ref7","first-page":"991","article-title":"Intracranial melanoma","volume":"20","author":"Terao","year":"1968","journal-title":"No To Shinkei"},{"key":"2024051919325649500_ref8","first-page":"1349","article-title":"Intracranial and intraspinal meningeal melanocytosis","volume":"21","author":"Painter","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024051919325649500_ref9","volume-title":"Central Nervous System Tumours","author":"Gessi","year":"2021"},{"key":"2024051919325649500_ref10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1684\/ejd.2021.4136","article-title":"Population-based analysis of the prevalence of BRAF mutation in patients diagnosed with cutaneous melanoma and its significance as a prognostic factor","volume":"31","author":"Rubi\u00f3-Casadevall","year":"2021","journal-title":"Eur J Dermatol"},{"key":"2024051919325649500_ref11","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1200\/JCO.2013.48.8718","article-title":"BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota","volume":"32","author":"Mu\u00f1oz-Hidalgo","year":"2014","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"2024051919325649500_ref12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.wneu.2015.03.061","article-title":"Primary meningeal melanocytoma in the left temporal lobe associated with nevus Ota: a case report and review of the literature","volume":"84","author":"Samadian","year":"2015","journal-title":"World Neurosurg"},{"key":"2024051919325649500_ref13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/CMR.0000000000000163","article-title":"Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature","volume":"25","author":"Shin","year":"2015","journal-title":"Melanoma Res"},{"key":"2024051919325649500_ref14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11060-009-9907-3","article-title":"Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota","volume":"95","author":"Navas","year":"2009","journal-title":"J Neurooncol"},{"key":"2024051919325649500_ref15","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1016\/j.wneu.2019.03.113","article-title":"Meningeal Melanocytoma associated with nevus of Ota: analysis of twelve reported cases","volume":"127","author":"Kuo","year":"2019","journal-title":"World Neurosurg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/5\/rjae332\/57742551\/rjae332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/5\/rjae332\/57742551\/rjae332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T19:33:13Z","timestamp":1716147193000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae332\/7676263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae332","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]},"article-number":"rjae332"}}