{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:05Z","timestamp":1753877165177,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Granular cell tumors are rare soft tissue neoplasms derived from Schwann cells and are characterized by their infiltrative, non-encapsulated nests and sheets of polygonal cells with fine eosinophilic cytoplasmic granules on histology. Herin, we report a case of a 10-year-old Saudi female who presented to the hospital with multiple asymptomatic skin lesions, the largest located on the right shoulder and left foot. Preoperative workup revealed the absence of liver metastasis, and the patient underwent complete surgical excision successfully. Histopathology revealed ill-defined proliferation of large bland cells with prominent eosinophilic granular cytoplasm and mild epithelial hyperplasia consistent with granular cell tumors. Granular cell tumors are a rare entity that represent only 0.5% of all soft tissue tumors. They have characteristic histological features and can present with both malignant and being features. Due to the rarity of this disease, further research is needed to enhance our understanding and improve recognition in future practice.<\/jats:p>","DOI":"10.1093\/jscr\/rjae384","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:05:55Z","timestamp":1717445155000},"source":"Crossref","is-referenced-by-count":0,"title":["Multiple cutaneous granular cell tumors involving the shoulder and foot in a child; a rare case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Baraa","family":"Amir","sequence":"first","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University, College of Medicine , Dammam 31441 , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-5360","authenticated-orcid":false,"given":"Amaar","family":"Amir","sequence":"additional","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University, College of Medicine , Dammam 31441 , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Pathology Services, Johns Hopkins Aramco Healthcare , Dhahran 34455 , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Aljahdali","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, Johns Hopkins Aramco Healthcare , Dhahran 34455 , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"2024060313333077200_ref1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4103\/2229-5178.190494","article-title":"Granular cell tumor in a child: an uncommon cutaneous presentation","volume":"7","author":"Grover","year":"2016","journal-title":"Indian Dermatol Online J"},{"key":"2024060313333077200_ref2","doi-asserted-by":"crossref","first-page":"152865","DOI":"10.1016\/j.prp.2020.152865","article-title":"Granular cell tumor a study of 42 cases and systemic review of the literature","volume":"216","author":"Mobarki","year":"2020","journal-title":"Patho - Res Pract"},{"key":"2024060313333077200_ref3","doi-asserted-by":"crossref","DOI":"10.5070\/D352J343MX","article-title":"Multiple cutaneous granular-cell tumors","volume":"13","author":"Hazan","year":"2007","journal-title":"Dermatol Online J"},{"key":"2024060313333077200_ref4","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1524-4725.2010.01492.x","article-title":"Mohs surgical excision of a granular cell tumor with plexiform features on the arm of a 7-year-old child","volume":"36","author":"Youssef","year":"2010","journal-title":"Dermatol Surg"},{"key":"2024060313333077200_ref5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0001-7310(09)70230-3","article-title":"Tumor de C\u00e9lulas Granulares Cut\u00e1neo","volume":"100","author":"Torrijos-Aguilar","year":"2009","journal-title":"Actas Dermosifiliogr"},{"key":"2024060313333077200_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.epsc.2016.08.001","article-title":"Report of two cases of granular cell tumor, a rare tumor in children","volume":"14","author":"Yasak","year":"2016","journal-title":"J Pediatr Surg Case Rep"},{"key":"2024060313333077200_ref7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00125480-199907000-00002","article-title":"Granular cell tumor: a review and update","volume":"6","author":"Ord\u00f3\u00f1ez","year":"1999","journal-title":"Adv Anat Pathol"},{"key":"2024060313333077200_ref8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1525-1470.2010.01111.x","article-title":"Multiple granular cell tumors in a child with Noonan syndrome","volume":"27","author":"Ramaswamy","year":"2010","journal-title":"Pediatr Dermatol"},{"key":"2024060313333077200_ref9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-0032-1322537","article-title":"Multiple granular cell tumors in a child with Noonan syndrome","volume":"23","author":"Oyen","year":"2012","journal-title":"Eur J Pediatr Surg"},{"key":"2024060313333077200_ref10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/DAD.0000000000002088","article-title":"Multifocal cutaneous granular cell tumor in children: a rare entity","volume":"44","author":"El-Khalawany","year":"2021","journal-title":"Am J Dermatopathol"},{"volume-title":"Granular Cell Tumor. 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