{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:18:13Z","timestamp":1774012693807,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Toxic megacolon denotes an abrupt non-obstructive distension of the colon, accompanied by systemic signs of toxicity. Mortality rates can soar as high as 7.9%. While primarily linked with chronic bowel conditions, the incidence attributed to Clostridioides difficile has surged due to the indiscriminate use of broad-spectrum antibiotics. Surgical intervention becomes necessary in the majority of cases. Herein, we illustrate the case of a 50-year-old female presenting with episodic epigastric pain lasting 9\u00a0h, vomiting, and watery bowel movements, devoid of peritoneal irritation findings and lacking a history of chronic intestinal inflammation. Under certain circumstances, toxic megacolon may manifest atypically, underscoring the importance of conducting a comprehensive medical history and clinical assessment. Moreover, it is imperative to solicit pertinent paraclinical investigations to address the patient holistically and foster a favorable clinical outcome.<\/jats:p>","DOI":"10.1093\/jscr\/rjae403","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:56:14Z","timestamp":1718135774000},"source":"Crossref","is-referenced-by-count":4,"title":["Toxic megacolon: a potentially lethal condition. Case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Jos\u00e9 Jes\u00fas","family":"Fabi\u00e1n-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Institute of Security and Social Services for State Workers , Tijuana, Baja California, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-1244","authenticated-orcid":false,"given":"Quitzia Libertad","family":"Torres-Salazar","sequence":"additional","affiliation":[{"name":"Ju\u00e1rez University of the State of Durango Faculty of Medicine and Nutrition, , Durango, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"2024061110000464200_ref1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.radi.2020.10.019","article-title":"CT features of toxic megacolon: a systematic review","volume":"27","author":"Eghbali","year":"2021","journal-title":"Radiography (Lond)"},{"key":"2024061110000464200_ref2","article-title":"Toxic megacolon in Clostridium difficile colitis","volume":"33","author":"Fukui","year":"2023","journal-title":"ID Cases"},{"key":"2024061110000464200_ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2147\/CEG.S200760","article-title":"Toxic megacolon: background, pathophysiology, management challenges and solutions","volume":"13","author":"Desai","year":"2020","journal-title":"Clin Exp Gastroenterol"},{"key":"2024061110000464200_ref4","first-page":"282","article-title":"Megacolon t\u00f3xico","volume":"28","author":"Carrillo-Esper","year":"2012","journal-title":"Med Int Mex"},{"key":"2024061110000464200_ref5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical Case Report (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int J Surg"},{"key":"2024061110000464200_ref6","volume-title":"StatPearls [Internet]","author":"Skomorochow","year":"2022"},{"key":"2024061110000464200_ref7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.22516\/25007440.256","article-title":"Megacolon toxic of idiophatic origin: case report","volume":"33","author":"Siado","year":"2018","journal-title":"Rev Colomb Gastroenterol"},{"key":"2024061110000464200_ref8","first-page":"168","article-title":"Clostridioides difficile infection: update on management","volume":"101","author":"Mounsey","year":"2020","journal-title":"Am Fam Physician"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/6\/rjae403\/58195233\/rjae403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/6\/rjae403\/58195233\/rjae403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:56:18Z","timestamp":1718135778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae403\/7690899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae403","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,6]]},"article-number":"rjae403"}}