{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:47:59Z","timestamp":1755798479775,"version":"3.41.2"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Orbital metastasis originating from breast carcinoma, particularly ductal carcinoma, represents a rare clinical entity, with lobular carcinoma usually being more common. Long-term surveillance in breast cancer patients is crucial for early detection of metastasis. Herein, we present a case of a 70-year-old woman with a history of left ductal breast carcinoma, diagnosed and treated 12\u00a0years ago. She then developed left eye vision loss, diplopia, enophthalmos, and chemosis in October 2024. Imaging revealed orbital metastasis involving the left superior and lateral rectus extraocular muscles. Biopsy confirmed the diagnosis of orbital metastases arising from ductal breast carcinoma. This case underscores the significance of long-term surveillance in breast cancer patients, as metastasis can manifest years after the initial diagnosis. Despite its rarity, orbital metastasis warrants consideration in the differential diagnosis of ocular symptoms in patients with a history of breast carcinoma. Treatment primarily aims at palliation and preserving visual function, with prognosis typically poor.<\/jats:p>","DOI":"10.1093\/jscr\/rjae428","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T12:25:50Z","timestamp":1719491150000},"source":"Crossref","is-referenced-by-count":2,"title":["Uncommon orbital metastasis in ductal breast carcinoma: a rare presentation 12\u00a0years after treatment"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-6949","authenticated-orcid":false,"given":"Kenza","family":"Horache","sequence":"first","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal","family":"Jidal","sequence":"additional","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenza","family":"Sidki","sequence":"additional","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Omor","sequence":"additional","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachida","family":"Latib","sequence":"additional","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Amalik","sequence":"additional","affiliation":[{"name":"Radiology Department , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"},{"name":"University of Medicine and Pharmacy of Rabat , National Institute of Oncology, , Av. Allal Al Fassi, Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"2024062712253024200_ref1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/BF00690473","article-title":"Metastasis of solid tumors in extraocular muscles","volume":"65","author":"Weiss","year":"1984","journal-title":"Acta Neuropathol"},{"key":"2024062712253024200_ref2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1159\/000509348","article-title":"Orbital metastasis from triple-negative breast cancer: case report and literature review","volume":"13","author":"El Bakraoui","year":"2020","journal-title":"Case Rep Oncol"},{"key":"2024062712253024200_ref3","doi-asserted-by":"crossref","first-page":"625663","DOI":"10.3389\/fendo.2021.625663","article-title":"Metastatic orbital tumor from breast ductal carcinoma with neuroendocrine differentiation initially presenting as ocular symptoms: a case report and literature review","volume":"12","author":"Togashi","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024062712253024200_ref4","first-page":"25","article-title":"Enophthalmos as the initial systemic finding of undiagnosed metastatic breast carcinoma","volume":"14","author":"El-Khazen Dupuis","year":"2021","journal-title":"Int Med Case Rep J"},{"key":"2024062712253024200_ref5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/cam4.331","article-title":"High frequency of lobular breast cancer in distant metastases to the orbit","volume":"4","author":"Raap","year":"2015","journal-title":"Cancer Med"},{"key":"2024062712253024200_ref6","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1503\/cmaj.120726","article-title":"Enophthalmos as a sign of metastatic breast carcinoma","volume":"185","author":"Novitskaya","year":"2013","journal-title":"CMAJ"},{"key":"2024062712253024200_ref7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1758-3284-3-37","article-title":"Orbital metastases as first sign of metastatic spread in breast cancer: case report and review of the literature","volume":"3","author":"Eckardt","year":"2011","journal-title":"Head Neck Oncol"},{"key":"2024062712253024200_ref8","first-page":"1353","article-title":"Eye metastasis in breast cancer: case report and review of literature","volume":"16","author":"Saad","year":"2022","journal-title":"Ecancermedicalscience"},{"key":"2024062712253024200_ref9","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/archopht.1987.01060090073031","article-title":"Metastatic tumors to the eye and orbit: patient survival and clinical characteristics","volume":"105","author":"Freedman","year":"1987","journal-title":"Arch Ophthalmol"},{"key":"2024062712253024200_ref10","doi-asserted-by":"crossref","first-page":"574086","DOI":"10.1155\/2015\/574086","article-title":"Ophthalmic metastasis of breast cancer and ocular side effects from breast cancer treatment and management: mini review","volume":"2015","author":"Georgalas","year":"2015","journal-title":"Biomed Res Int"},{"key":"2024062712253024200_ref11","first-page":"91","article-title":"Orbital metastasis of breast carcinoma","volume":"3","author":"Vlachostergios","year":"2009","journal-title":"Breast Cancer (Auckl)"},{"key":"2024062712253024200_ref12","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijscr.2020.12.049","article-title":"An early orbital metastasis from breast cancer: a case report","volume":"78","author":"Razem","year":"2021","journal-title":"Int J Surg Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/6\/rjae428\/58345361\/rjae428.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/6\/rjae428\/58345361\/rjae428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T12:25:59Z","timestamp":1719491159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae428\/7700057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae428","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,6]]},"article-number":"rjae428"}}