{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:48:11Z","timestamp":1788929291046,"version":"build-2803163510"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary lacrimal sac lymphoma is a rare condition, often presenting with nasolacrimal duct obstruction. Herein, we present a unique case of diffuse large B-cell lymphoma (DLBCL) involving the lacrimal sac, maxillary sinus, and infraorbital nerve. Prompt diagnosis via biopsy is essential for timely treatment and the prevention of tumor progression. A 66-year-old female presented with intractable epiphora, infraorbital nerve hypesthesia, and medial canthal swelling. Imaging revealed a soft tissue mass in the right maxillary sinus extending into the right inferior orbit and nasal cavity. A biopsy confirmed DLBCL, prompting systemic chemotherapy. Residual disease prompted high-dose involved-site radiation, resulting in tumor regression. To our knowledge, this is the first case of primary DLBCL of the lacrimal sac with concurrent involvement of the maxillary sinus and infraorbital nerve. This case underscores the significance of lacrimal sac biopsy in refractory dacryocystitis or unilateral sinus disease and the effectiveness of multimodal treatment approaches in managing DLBCL.<\/jats:p>","DOI":"10.1093\/jscr\/rjae453","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T20:12:25Z","timestamp":1721506345000},"source":"Crossref","is-referenced-by-count":5,"title":["Primary diffuse large B-cell lymphoma of the lacrimal sac with involvement of maxillary sinus: a case report and review of literature"],"prefix":"10.1093","volume":"2024","author":[{"given":"Birkaran","family":"Sadhar","sequence":"first","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine , Erie, PA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Slupek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center Hamot , Erie, PA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4697","authenticated-orcid":false,"given":"Andrew","family":"Steehler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center Hamot , Erie, PA , United States"},{"name":"ENT Specialists of Northwestern Pennsylvania , Erie, PA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Denne","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center Hamot , Erie, PA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Steehler","sequence":"additional","affiliation":[{"name":"ENT Specialists of Northwestern Pennsylvania , Erie, PA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"2024072020121888100_ref1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/IOP.0000000000001997","article-title":"Lymphoma of the lacrimal sac: the Massachusetts eye and ear experience with a comparison to the previously reported literature","volume":"38","author":"Neerukonda","year":"2022","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2024072020121888100_ref2","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1097\/SCS.0000000000007861","article-title":"Diffuse large B-cell lymphoma arising in the lacrimal sac","volume":"33","author":"Kim","year":"2022","journal-title":"J Craniofac Surg"},{"key":"2024072020121888100_ref3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.pas.0000213350.49767.46","article-title":"Lymphoma of the ocular adnexa: a study of 353 cases","volume":"31","author":"Ferry","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2024072020121888100_ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1442-9071.2001.d01-18.x","article-title":"Ocular adnexal lymphoproliferative disease: a series of 73 cases","volume":"29","author":"McKelvie","year":"2001","journal-title":"Clin Exp Ophthalmol"},{"key":"2024072020121888100_ref5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/bjo.84.8.907","article-title":"Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival","volume":"84","author":"Jenkins","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"2024072020121888100_ref6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hon.741","article-title":"Ophthalmologic and intraocular non-Hodgkin's lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors","volume":"22","author":"Meunier","year":"2004","journal-title":"Hematol Oncol"},{"key":"2024072020121888100_ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.anorl.2010.09.001","article-title":"Malignant lacrimal sac tumors","volume":"127","author":"Montalban","year":"2010","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"2024072020121888100_ref8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1182\/blood-2006-02-005017","article-title":"Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options","volume":"108","author":"Decaudin","year":"2006","journal-title":"Blood"},{"key":"2024072020121888100_ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7181\/acfs.2022.00612","article-title":"Lacrimal sac lymphoma: a case report","volume":"23","author":"Ueathaweephol","year":"2022","journal-title":"Arch Craniofac Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/7\/rjae453\/58603971\/rjae453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/7\/rjae453\/58603971\/rjae453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T20:12:30Z","timestamp":1721506350000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae453\/7717608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae453","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,7,1]]},"article-number":"rjae453"}}