{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:40:42Z","timestamp":1769074842819,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cellular angiofibroma is a rare benign mesenchymal tumor, typically occurring in the vulvar region of middle-aged women. This report highlights the importance of histological analysis in diagnosing this uncommon condition and emphasizes its benign nature and straightforward management. We present a case of a 58-year-old North African woman who had a large, well-defined mass in the left labia majora, which had been evolving over 2\u00a0years. MRI confirmed the resectability of the tumor by delineating its boundaries. The tumor, despite its slow growth leading to delayed diagnosis, was effectively treated with wide surgical excision. Diagnosis was confirmed through histological and immunohistochemical evaluations, revealing spindle cell proliferation with thick-walled vessels. Cellular angiofibroma, although initially alarming due to its size, is generally managed successfully with surgery and prognosis is favorable with a low risk of recurrence.<\/jats:p>","DOI":"10.1093\/jscr\/rjae508","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T21:14:52Z","timestamp":1723583692000},"source":"Crossref","is-referenced-by-count":2,"title":["Massive cellular angiofibroma of the vulva: a case report"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-3176","authenticated-orcid":false,"given":"Hounaida","family":"Mahfoud","sequence":"first","affiliation":[{"name":"Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissam","family":"Bensrhir","sequence":"additional","affiliation":[{"name":"Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Abbouch","sequence":"additional","affiliation":[{"name":"Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chourouq","family":"Mustapha Eid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariame","family":"Meziane","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Sassi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najat","family":"Lamalmi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najia","family":"Zeraidi","sequence":"additional","affiliation":[{"name":"Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Baidada","sequence":"additional","affiliation":[{"name":"Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V , Rabat 10100, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"2024081321144327300_ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2559.2000.00865.x","article-title":"Vulvovaginal soft tissue tumours: update and review","volume":"36","author":"Nucci","year":"2000","journal-title":"Histopathology"},{"key":"2024081321144327300_ref2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12907-016-0030-z","article-title":"Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review","volume":"16","author":"Khmou","year":"2016","journal-title":"BMC Clin Pathol"},{"key":"2024081321144327300_ref3","first-page":"e29250","article-title":"Aggressive angiomyxoma, angiomyofibroblastoma, and cellular angiofibroma of the lower female genital tract: related entities with 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vulva","volume":"21","author":"Santiago","year":"2017","journal-title":"J Low Genit Tract Dis"},{"key":"2024081321144327300_ref11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.path.2018.07.008","article-title":"Mesenchymal neoplasms of the genitourinary system","volume":"11","author":"Hatfield","year":"2018","journal-title":"Surg Pathol Clin"},{"key":"2024081321144327300_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2021.11.006","article-title":"Cellular angiofibroma arising in the anorectal region: clinicopathologic and immunohistochemical analysis of five cases","volume":"120","author":"Matsumoto","year":"2022","journal-title":"Hum Pathol"},{"key":"2024081321144327300_ref13","doi-asserted-by":"crossref","first-page":"e00295","DOI":"10.1016\/j.crwh.2021.e00295","article-title":"Transperineal excision of a sizeable angiofibroma of the ischiorectal fossa. 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