{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:20Z","timestamp":1753877180467,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant melanoma, a highly aggressive skin cancer, accounts for 75% of skin cancer-related deaths. This case report details a 59-year-old Sudanese male with a malignant melanoma of the left foot, presenting with nodal melanosis, a rare condition involving benign pigmented deposits in the lymph nodes. The patient underwent below-knee amputation and inguinal lymph node dissection. Significant black discoloration was observed in the lymph nodes, indicating nodal melanosis. Histopathological examination of excised lymph nodes confirmed the presence of both malignant melanoma and benign melanosis. Despite surgical intervention, the patient eventually developed distant metastases, including lung nodules and a liver lesion. This case underscores the importance of recognizing nodal melanosis in metastatic malignant melanoma and highlights the challenges of managing advanced cases in resource-limited settings. Surgical management remains critical, particularly wide resection and lymph node dissection, even as systemic therapies advance.<\/jats:p>","DOI":"10.1093\/jscr\/rjae591","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T23:21:58Z","timestamp":1726701718000},"source":"Crossref","is-referenced-by-count":1,"title":["Nodal melanosis in malignant melanoma: a rare case from the Middle East with comprehensive surgical and histopathological findings"],"prefix":"10.1093","volume":"2024","author":[{"given":"Alsadig","family":"Suliman","sequence":"first","affiliation":[{"name":"Department of General Surgery, Sudan Medical Specialization Board , Isbitalia Street, Downtown, Khartoum, Khartoum 13315, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Mohamed Osman","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Al-Neelain University , Zubeir Pasha Street, Downtown, Khartoum, Khartoum 11115, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"SeedAhmed","sequence":"additional","affiliation":[{"name":"General Surgery, Wad Madani Teaching Hospital , Hospital Street, Downtown, Wad Madani 21111, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"volume-title":"StatPearls [Internet]","year":"2024","author":"Heistein","key":"2024091823215101900_ref1"},{"key":"2024091823215101900_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1021057","article-title":"Melanoma lymph node metastases \u2013 moving beyond quantity in clinical trial design and contemporary practice","volume":"12","author":"Rhodin","year":"2022","journal-title":"Front Oncol"},{"article-title":"Melanoma skin cancer statistics","year":"2024","author":"Cancer Research UK","key":"2024091823215101900_ref3"},{"volume-title":"Global Cancer Observatory: Cancer Today","author":"","key":"2024091823215101900_ref4"},{"key":"2024091823215101900_ref5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4236\/ojpathology.2017.74007","article-title":"Clinicopathological pattern of basal cell carcinoma among Sudanese patients open access","volume":"7","author":"Mohammed","year":"2017","journal-title":"Open J Pathol"},{"key":"2024091823215101900_ref6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5152\/TurkJPlastSurg.2017.2072","article-title":"Malignant melanoma with simultaneous inguinal and popliteal lymph node metastases: a rare case report","volume":"25","author":"Karadag","year":"2017","journal-title":"Turk J Plast Surg"},{"key":"2024091823215101900_ref7","doi-asserted-by":"publisher","first-page":"109916","DOI":"10.1016\/j.ijporl.2020.109916","article-title":"Benign tumoral melanosis of a cervical lymph node in a child","volume":"132","author":"Boscoe","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2024091823215101900_ref8","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1600-0560.2006.00609.x","article-title":"Tumoral melanosis involving the sentinel lymph nodes: a case report","volume":"34","author":"Satzger","year":"2007","journal-title":"J Cutan Pathol"},{"key":"2024091823215101900_ref9","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.5858\/133.8.1332","article-title":"Lymph node melanosis in a patient with metastatic melanoma of unknown primary","volume":"133","author":"Malafronte","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"2024091823215101900_ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.36876\/smdj.1014","article-title":"Sentinel lymph node melanosis: a report of two cases of regressed melanoma metastases","volume":"3","author":"Sun","year":"2017","journal-title":"SM Dermatol J"},{"key":"2024091823215101900_ref11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/jdv.12906","article-title":"Lymph node melanosis. Should it be managed as a high-risk melanoma? A case report and review of the literature","volume":"30","author":"Solano-L\u00f3pez","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024091823215101900_ref12","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.21873\/anticanres.13452","article-title":"Clinical outcomes of isolated regional lymph node recurrence in patients with malignant cutaneous melanoma","volume":"39","author":"Kwon","year":"2019","journal-title":"Anticancer Res"},{"key":"2024091823215101900_ref13","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1056\/NEJMoa060992","article-title":"Sentinel-node biopsy or nodal observation in melanoma","volume":"355","author":"Morton","year":"2006","journal-title":"N Engl J Med"},{"key":"2024091823215101900_ref14","doi-asserted-by":"publisher","first-page":"E198","DOI":"10.1503\/cjs.012022","article-title":"Predictors of complication after groin dissection: a single-centre experience","volume":"67","author":"Jamjoum","year":"2024","journal-title":"Can J Surg"},{"key":"2024091823215101900_ref15","doi-asserted-by":"publisher","first-page":"1181728","DOI":"10.3389\/fonc.2023.1181728","article-title":"Case report: malignant melanoma of the lower limb with gastric metastasis","volume":"13","author":"Hu","year":"2023","journal-title":"Front Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/9\/rjae591\/59180676\/rjae591.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/9\/rjae591\/59180676\/rjae591.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T23:22:00Z","timestamp":1726701720000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae591\/7760025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae591","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9]]},"article-number":"rjae591"}}