{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:35:55Z","timestamp":1783722955506,"version":"3.55.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Healthcare-associated central nervous system infections are a significant complication for patients undergoing neurosurgical interventions. We present a case of a 6-year-old patient with an embryonal tumor of the central nervous system. Following a craniotomy for the resection of the tumor, an external ventricular drainage was placed. Several weeks after surgery, she developed signs of meningism. Cerebrospinal fluid cultures were positive for pan-drug resistant Acinetobacter baumannii. Several revisions with the insertion of new external valves were done. She was treated with intravenously meropenem and vancomycin combined with colistin administrated intraventricularly. Significant improvement was seen clinically with negative cultures after 2\u00a0weeks. The synergistic action of colistin administrated locally combined with systemic antibiotics may be a promising option for critically ill patients with pan-drug resistant A. baumannii central nervous system infection.<\/jats:p>","DOI":"10.1093\/jscr\/rjae603","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T18:11:30Z","timestamp":1727115090000},"source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment of pan-drug resistant <i>Acinetobacter baumannii<\/i> meningitis\/ventriculitis following craniotomy and external ventricular drainage: a case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Aleksandra Dimovska","family":"Gavrilovska","sequence":"first","affiliation":[{"name":"University Clinic of Neurosurgery, Clinical Center \u201cMother Theresa\u201d , 1000 Skopje, Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristijan","family":"Veljanovski","sequence":"additional","affiliation":[{"name":"University Clinic of Neurosurgery, Clinical Center \u201cMother Theresa\u201d , 1000 Skopje, Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radomir","family":"Jovchevski","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Parasitology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje , 50 Divizija 6, 1000 Skopje, Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"2024092318111523600_ref1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.53854\/liim-3101-14","article-title":"Successful treatment of pan-drug resistant Acinetobacter baumannii nosocomial meningitis\/ventriculitis by combined intravenous and intrathecal colistin-tigecycline administration: a case series","volume":"31","author":"Theofanopoulos","year":"2023","journal-title":"Infez Med"},{"key":"2024092318111523600_ref2","first-page":"3","article-title":"Intrathecal or intraventricular colistin: a review","volume":"24","author":"Bargiacchi","year":"2016","journal-title":"Infez Med"},{"key":"2024092318111523600_ref3","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s42399-020-00433-7","article-title":"Intraventricular tigecycline as a last resort therapy in a patient with difficult-to-treat healthcare-associated Acinetobacter baumannii ventriculitis: a case report","volume":"2","author":"Abdallah","year":"2020","journal-title":"SN Compr Clin Med"},{"key":"2024092318111523600_ref4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1089\/sur.2018.286","article-title":"Clinical presentations and outcomes of post-operative central nervous system infection caused by multi-drug-resistant\/extensively drug-resistant Acinetobacter baumannii: a retrospective study","volume":"20","author":"Liang","year":"2019","journal-title":"Surg Infect (Larchmt)"},{"key":"2024092318111523600_ref5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jcrc.2018.07.025","article-title":"Intraventricular CNS treatment with colistin-tigecycline combination: a case series","volume":"47","author":"Tsolaki","year":"2018","journal-title":"J Crit Care"},{"key":"2024092318111523600_ref6","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3390\/biom10050720","article-title":"Carbapenemases: transforming Acinetobacter baumannii into a yet more dangerous menace","volume":"10","author":"Ramirez","year":"2020","journal-title":"Biomolecules"},{"key":"2024092318111523600_ref7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.pharmthera.2017.07.012","article-title":"Polymyxins for CNS infections: pharmacology and neurotoxicity","volume":"181","author":"Velkov","year":"2018","journal-title":"Pharmacol Ther"},{"key":"2024092318111523600_ref8","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1186\/s12879-020-05321-y","article-title":"Multidrug resistant and extensively drug resistant Acinetobacter baumannii hospital infection associated with high mortality: a retrospective study in the pediatric intensive care unit","volume":"20","author":"Shi","year":"2020","journal-title":"BMC Infect Dis"},{"key":"2024092318111523600_ref9","doi-asserted-by":"publisher","first-page":"6029","DOI":"10.2147\/IDR.S425415","article-title":"Treatment of central nervous system infection caused by multidrug-resistant Acinetobacter baumannii with intravenous and intraventricular colistin sulfate: a case report and literature review","volume":"16","author":"Yang","year":"2023","journal-title":"Infect Drug Resist"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/9\/rjae603\/59242801\/rjae603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/9\/rjae603\/59242801\/rjae603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T18:11:31Z","timestamp":1727115091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae603\/7765474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae603","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9]]},"article-number":"rjae603"}}