{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:39:31Z","timestamp":1789000771066,"version":"build-2803163510"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This case report highlights the clinical presentation and surgical management of a 27-year-old man with recurrent pancreatitis attributed to a homozygous SPINK1 (N34S) mutation. The patient, who experienced multiple hospital admissions, underwent extensive diagnostic evaluations, including imaging and genetic testing, confirming the hereditary nature of his condition. Despite unsuccessful endoscopic interventions, a laparoscopic Puestow procedure was performed, aiming to alleviate symptoms and improve pancreatic drainage. Postoperatively, the patient's recovery was successful, and he was discharged with supplemental pancreatic enzyme therapy. The differential diagnosis included autoimmune pancreatitis and non-hereditary chronic pancreatitis. This case underscores the challenges and considerations in the diagnosis and management of hereditary pancreatitis associated with SPINK1 mutations, emphasizing the role of surgical interventions for selected cases.<\/jats:p>","DOI":"10.1093\/jscr\/rjae614","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:47:40Z","timestamp":1728017260000},"source":"Crossref","is-referenced-by-count":1,"title":["Puestow surgery in a SPINK mutation chronic pancreatitis: a rare case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Paola","family":"Solis-Pazmino","sequence":"first","affiliation":[{"name":"Department of General Surgery, Santa Casa de Miseric\u00f3rdia de Porto Alegre , Porto Alegre ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Hospital Pablo Arturo Su\u00e1rez , Quito 170103 ,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Gordon","sequence":"additional","affiliation":[{"name":"Hospital Pablo Arturo Su\u00e1rez , Quito 170103 ,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Clavijo","sequence":"additional","affiliation":[{"name":"Hospital del R\u00edo , AK Y, Av. 24 de Mayo, - Cant\u00f3n, Cuenca 010109 ,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Santa Casa de Miseric\u00f3rdia de Porto Alegre , Porto Alegre ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Lincango","sequence":"additional","affiliation":[{"name":"CaTaLiNa: Thyroid Cancer in Latin America , Quito ,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Cede\u00f1o","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Santa Casa de Miseric\u00f3rdia de Porto Alegre , Porto Alegre ,","place":["Brazil"]},{"name":"Interhospital S.A. Guayaquil , 140401 ,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"2024100404473473500_ref1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.ebiom.2019.09.032","article-title":"Natural history of SPINK1 germline mutation related-pancreatitis","volume":"48","author":"Muller","year":"2019","journal-title":"EBioMedicine"},{"key":"2024100404473473500_ref2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.5694\/mja2.51517","article-title":"The clinical and genetic features of hereditary pancreatitis in South Australia","volume-title":"Med J Aust","author":"Wu","year":"2022"},{"key":"2024100404473473500_ref3","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/j.jpedsurg.2013.03.048","article-title":"Modified Puestow procedure for the management of chronic pancreatitis in children","volume":"48","author":"Laje","year":"2013","journal-title":"J Pediatr Surg"},{"key":"2024100404473473500_ref4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.surge.2019.07.002","article-title":"Laparoscopic longitudinal pancreaticojejunostomy for chronic pancreatitis: systematic review of the literature","volume":"18","author":"Ramia","year":"2020","journal-title":"Surgeon"},{"key":"2024100404473473500_ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5409\/wjcp.v11.i1.27","article-title":"Hereditary pancreatitis: an updated review in pediatrics","volume":"11","author":"Panchoo","year":"2022","journal-title":"World J Clin Pediatr"},{"key":"2024100404473473500_ref6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cgh.2020.03.047","article-title":"Differences in age at onset of symptoms, and effects of genetic variants, in patients with early vs late-onset idiopathic chronic pancreatitis in a north American cohort","volume":"19","author":"Lewis","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024100404473473500_ref7","doi-asserted-by":"publisher","first-page":"5624","DOI":"10.1007\/s00464-016-4920-z","article-title":"Laparoscopic Puestow: lateral pancreaticojejunostomy","volume":"30","author":"Biteman","year":"2016","journal-title":"Surg Endosc"},{"key":"2024100404473473500_ref8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4103\/jiaps.JIAPS_235_18","article-title":"Laparoscopic Puestow procedure for chronic pancreatitis in children","volume":"25","author":"Arora","year":"2020","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"2024100404473473500_ref9","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1089\/lap.2018.0136","article-title":"Lateral Pancreaticojejunostomy for chronic pancreatitis and pancreatic ductal dilation in children","volume":"28","author":"Shah","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/10\/rjae614\/59555449\/rjae614.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/10\/rjae614\/59555449\/rjae614.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:47:42Z","timestamp":1728017262000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae614\/7808938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae614","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10,1]]},"article-number":"rjae614"}}