{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:03:34Z","timestamp":1793361814513,"version":"4.5.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Angiosarcoma, a rare endothelial cell tumor, accounts for &amp;lt; 2% of all sarcomas, typically affecting elderly patients. We present the case of a 62-year-old male with a history of hypertension and ischemic heart disease, who initially presented with severe lower back pain. Subsequent imaging revealed a ruptured splenic lesion and multiple liver lesions, leading to a diagnosis of stage 4 angiosarcoma. Post-splenectomy, the patient exhibited pathological vertebral fractures and elevated liver function tests, consistent with metastatic disease. Despite aggressive surgical intervention and supportive care, the patient\u2019s condition remained critical. The treatment plan included palliative chemotherapy, spine radiotherapy, and ongoing pain management, with close monitoring of disease progression and response to therapy. This case describes the diagnostic challenges and poor prognosis associated with metastatic angiosarcoma.<\/jats:p>","DOI":"10.1093\/jscr\/rjae633","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T18:50:16Z","timestamp":1728413416000},"source":"Crossref","is-referenced-by-count":8,"title":["Spontaneous splenic rupture as a primary manifestation of angiosarcoma: a case report"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5122-8200","authenticated-orcid":false,"given":"Ameer","family":"Awashra","sequence":"first","affiliation":[{"name":"An Najah National University Department of Medicine, , Nablus P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Sawaftah","sequence":"additional","affiliation":[{"name":"An Najah National University Department of Medicine, , Nablus P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Bani","family":"Odah","sequence":"additional","affiliation":[{"name":"An Najah National University Department of Medicine, , Nablus P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Sawafta","sequence":"additional","affiliation":[{"name":"An Najah National University Department of Medicine, , Nablus P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Khatib","sequence":"additional","affiliation":[{"name":"Tubas Turkish Governmental Hospital Department of Surgery, , Tubas P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huthayfa","family":"Dababat","sequence":"additional","affiliation":[{"name":"Tubas Turkish Governmental Hospital Department of Surgery, , Tubas P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Yasin","sequence":"additional","affiliation":[{"name":"Tubas Turkish Governmental Hospital Department of Surgery, , Tubas P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Khamaysa","sequence":"additional","affiliation":[{"name":"Tubas Turkish Governmental Hospital Department of Radiology, , Tubas P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muath","family":"Daraghmeh","sequence":"additional","affiliation":[{"name":"Patient\u2019s Friends Society Department of Radiology, , Nablus P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"2024100818500270000_ref1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.annpat.2011.04.002","article-title":"Angiosarcome de haut grade de l\u2019il\u00e9on associ\u00e9 \u00e0 Une angiosarcomatose\u00a0: \u00e0 propos d\u2019une observation","volume":"31","author":"Chahbouni","year":"2011","journal-title":"Ann Pathol"},{"key":"2024100818500270000_ref2","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3390\/cancers15072025","article-title":"Diagnosis, prognosis, and treatment of canine hemangiosarcoma: a review based on a consensus organized by the Brazilian Association of Veterinary Oncology, ABROVET","volume":"15","author":"De Nardi","year":"2023","journal-title":"Cancer"},{"key":"2024100818500270000_ref3","doi-asserted-by":"publisher","first-page":"1257284","DOI":"10.1155\/2018\/1257284","article-title":"Primary peritoneal angiosarcoma metastatic to liver and bone without history of radiation therapy","volume":"2018","author":"Chiang","year":"2018","journal-title":"Case Rep Pathol"},{"key":"2024100818500270000_ref4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S1726-4901(08)70019-4","article-title":"Duodenal angiosarcoma: an unusual cause of severe gastrointestinal bleeding","volume":"70","author":"Chen","year":"2007","journal-title":"J Chin Med Assoc: JCMA"},{"key":"2024100818500270000_ref5","doi-asserted-by":"publisher","first-page":"294","DOI":"10.14740\/jocmr3153w","article-title":"Primary small intestinal angiosarcoma: epidemiology, diagnosis and treatment","volume":"10","author":"Nai","year":"2018","journal-title":"J Clin Med Res"},{"key":"2024100818500270000_ref6","first-page":"404","article-title":"A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding","volume":"46","author":"Ryu","year":"2005","journal-title":"Korean J Gastroenterol = Taehan Sohwagi Hakhoe chi"},{"key":"2024100818500270000_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-2-133","article-title":"Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report","volume":"2","author":"Manouras","year":"2008","journal-title":"J Med Case Reports"},{"key":"2024100818500270000_ref8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.32635\/2176-9745.rbc.1998v44n1.2800","article-title":"Primary splenic angiosarcoma: case report and literature review","volume":"92","author":"Hai","year":"2000","journal-title":"J Natl Med Assoc"},{"key":"2024100818500270000_ref9","first-page":"217","article-title":"Primary splenic angiosarcoma associated with anemia, leukocytosis and thrombocytopenia","volume":"44","author":"Aqil","year":"2014","journal-title":"Ann Clin Lab Sci"},{"key":"2024100818500270000_ref10","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/MODPATHOL.3880178","article-title":"Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases","volume":"13","author":"Neuhauser","year":"2000","journal-title":"Mod Pathol"},{"key":"2024100818500270000_ref11","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1097\/00000478-199310000-00001","article-title":"Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases","volume":"17","author":"Falk","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"2024100818500270000_ref12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1148\/RADIOL.2351040308","article-title":"Angiosarcoma of the spleen: imaging characteristics in 12 patients","volume":"235","author":"Thompson","year":"2005","journal-title":"Radiology"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/10\/rjae633\/59638548\/rjae633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/10\/rjae633\/59638548\/rjae633.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T18:50:17Z","timestamp":1728413417000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae633\/7815657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae633","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10,1]]},"article-number":"rjae633"}}