{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:54:53Z","timestamp":1793123693631,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K08CA276706-01A1"],"award-info":[{"award-number":["1K08CA276706-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Postsurgical pyoderma gangrenosum (PSPG) is a rare, ulcerative skin condition that presents a diagnostic challenge due to its similar presentation to infectious etiologies in the postsurgical period\u2014often leading to gratuitous and unnecessary surgery and antibiotic use. We report a 37-year-old female with breast cancer who received neoadjuvant chemotherapy and immunotherapy and underwent bilateral skin-sparing mastectomies who developed delayed bilateral mastectomy skin flap necrosis secondary to PSPG. This case had rare factors associated with the development of PSPG such as preoperative systemic therapy and a familial component. This case underscores the importance of early recognition of this rare disease and appropriate management of PSPG to prevent unnecessary interventions and ensure an optimal outcome.<\/jats:p>","DOI":"10.1093\/jscr\/rjae667","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T16:34:37Z","timestamp":1729614877000},"source":"Crossref","is-referenced-by-count":5,"title":["Postsurgical pyoderma gangrenosum after mastectomy with a familial component"],"prefix":"10.1093","volume":"2024","author":[{"given":"Christine Courtney","family":"Rogers","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology , Department of Surgery, , Milwaukee, WI 53226 ,","place":["United States"]},{"name":"Medical College of Wisconsin , Department of Surgery, , Milwaukee, WI 53226 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Nepper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Milwaukee, WI 53226 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra E","family":"Holzem","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Milwaukee, WI 53226 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler S","family":"Cortina","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology , Department of Surgery, , Milwaukee, WI 53226 ,","place":["United States"]},{"name":"Medical College of Wisconsin , Department of Surgery, , Milwaukee, WI 53226 ,","place":["United States"]},{"name":"Medical College of Wisconsin Cancer Center , Milwaukee, WI 53226 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"2024102216342627100_ref1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.jaad.2015.06.021","article-title":"Pathophysiology of pyoderma gangrenosum (PG): an updated review","volume":"73","author":"Braswell","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"2024102216342627100_ref2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.7861\/clinmedicine.19-3-224","article-title":"Pyoderma gangrenosum - a guide to diagnosis and management","volume":"19","author":"George","year":"2019","journal-title":"Clin Med (Lond)"},{"key":"2024102216342627100_ref3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3390\/j4030028","article-title":"Pyoderma gangrenosum: a review of updates in diagnosis, pathophysiology and management","volume":"4","author":"Skopis","year":"2021","journal-title":"J"},{"key":"2024102216342627100_ref4","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1097\/SAP.0000000000002101","article-title":"A deceptive diagnosis: pyoderma gangrenosum after breast surgery\u2014a case series and literature review","volume":"83","author":"Mella","year":"2019","journal-title":"Ann Plast Surg"},{"key":"2024102216342627100_ref5","doi-asserted-by":"publisher","first-page":"e13074","DOI":"10.1111\/dth.13074","article-title":"Neutrophilic dermatoses as adverse effects of checkpoint inhibitors: a review","volume":"32","author":"Ravi","year":"2019","journal-title":"Dermatol Ther"},{"key":"2024102216342627100_ref6","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1111\/bjd.13493","article-title":"The genetics of pyoderma gangrenosum and implications for treatment: a systematic review","volume":"172","author":"DeFilippis","year":"2015","journal-title":"Br J Dermatol"},{"key":"2024102216342627100_ref7","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). 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