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In HIV-infected individuals, an impaired immune system significantly diminishes the body\u2019s capacity to combat infections and inflammation, thereby complicating the healing process of anal fistulas. Moreover, the impact of HIV on tissue repair results in a markedly prolonged healing process for wounds and tissue damage in these patients, exacerbating the difficulty in anal fistula resolution. Chronic anal fistulas that remain untreated for extended periods not only severely impair the patient\u2019s quality of life but also pose an increased risk of malignant transformation.<\/jats:p>","DOI":"10.1093\/jscr\/rjae686","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:55:12Z","timestamp":1730854512000},"source":"Crossref","is-referenced-by-count":1,"title":["Squamous cell carcinoma arising from anal fistula in an HIV-positive individual: a case report"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-7779","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Anorectal Department, Shijiazhuang Traditional Chinese Medical Hospital , 233 Zhongshan Road, Shijiazhuang 050001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anorectal Department, Shijiazhuang Traditional Chinese Medical Hospital , 233 Zhongshan Road, Shijiazhuang 050001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Anorectal Department, Shijiazhuang Traditional Chinese Medical Hospital , 233 Zhongshan Road, Shijiazhuang 050001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"Anorectal Department, Shijiazhuang Traditional Chinese Medical Hospital , 233 Zhongshan Road, Shijiazhuang 050001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"2024110600550508000_ref1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s40792-023-01743-3","article-title":"A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess","volume":"9","author":"Koizumi","year":"2023","journal-title":"Surg Case Rep"},{"key":"2024110600550508000_ref2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1272\/jnms.74.319","article-title":"Squamous cell carcinoma arising from recurrent anal fistula","volume":"74","author":"Seya","year":"2007","journal-title":"J Nippon Med Sch"},{"key":"2024110600550508000_ref3","first-page":"117","article-title":"Anal mucinous adenocarcinoma arising in long standing fistula-in-ano","volume":"147","author":"Itah","year":"2008","journal-title":"Harefuah"},{"volume":"35","journal-title":"Trans Am Proctol Soc","key":"2024110600550508000_ref4"},{"key":"2024110600550508000_ref5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1007\/s12094-017-1750-y","article-title":"Mucinous adenocarcinoma on perianal fistula. 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