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Inherited diseases of DNA mismatch repair (MMR) can cause multiple cancers in the same patient including CRC and GBM. In this study, we report a 59-year-old woman presented with fatigue, constipation, abdominal distention, perianal pain, right-sided arm weakness, and personality changes. After investigations, it was diagnosed that sporadic metastatic CRC and GBM occurred simultaneously in the same patient, which was confirmed by colonoscopy, biopsy, imaging, and molecular testing. As the treatment of two cancers in the same patient is unique and complex, the absence of guidelines for such cases was discussed in a multidisciplinary tumor board including surgeons, medical, and radiation oncologists.<\/jats:p>","DOI":"10.1093\/jscr\/rjae708","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T16:44:01Z","timestamp":1739810641000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare case of sporadic metastatic colorectal cancer with glioblastoma multiforme: a challenging clinical scenario"],"prefix":"10.1093","volume":"2025","author":[{"given":"Farah","family":"Awad","sequence":"first","affiliation":[{"name":"Oncology Department, Augusta Victoria Hospital, East Jerusalem ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University , University Street, Abu Dis, Jerusalem District, 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