{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:10:18Z","timestamp":1774476618715,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Carotid body tumors (CBTs) are rare head and neck paragangliomas that arise from the carotid body chemoreceptor at the common carotid bifurcation. These neoplasms are generally benign, slow-growing, nonsecreting, and well-vascularized. Metastasis occurs in ~5% of cases. Here, we report a case of a 35-year-old female presenting with 1-year history of a growing left neck mass, consistent with a CBT. Patient ultimately underwent surgical excision and was found to have a malignant paraganglioma with metastases to cervical lymph nodes. She was further treated with a left modified radical neck dissection and adjuvant radiotherapy and remains disease-free at the time of follow-up 2 years later. We discuss the roles of preoperative assessment, concomitant selective neck dissection and tumor resection, and subsequent modified radical neck dissection as part of the diagnosis and surgical management of malignant CBTs.<\/jats:p>","DOI":"10.1093\/jscr\/rjae811","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T11:01:03Z","timestamp":1735210863000},"source":"Crossref","is-referenced-by-count":1,"title":["Treatment of metastatic carotid body paraganglioma in a young female"],"prefix":"10.1093","volume":"2025","author":[{"given":"Aldin","family":"Malkoc","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Kaiser Permanente Fontana Medical Center , 9961 Sierra Ave, Fontana, CA 92335 ,","place":["United States"]},{"name":"Division of Vascular Surgery, Department of Surgery, Arrowhead Regional Medical Center , 400 N Pepper Ave, Colton, CA 92324 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Arrowhead Regional Medical Center , 400 N Pepper Ave, Colton, CA 92324 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Arrowhead Regional Medical Center , 400 N Pepper Ave, Colton, CA 92324 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iden","family":"Andacheh","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Arrowhead Regional Medical Center , 400 N Pepper Ave, Colton, CA 92324 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"2024122611005344300_ref1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1080\/02688697.2019.1617404","article-title":"The carotid body and associated tumors: updated review with clinical\/surgical significance","volume":"33","author":"Butt","year":"2019","journal-title":"Br J Neurosurg"},{"key":"2024122611005344300_ref2","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s00405-019-05740-x","article-title":"Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients","volume":"277","author":"Gu","year":"2020","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2024122611005344300_ref3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1177\/0145561319863373","article-title":"Is regional lymph node metastasis of head and neck paraganglioma a sign of aggressive clinical behavior: a clinical\/pathologic review","volume":"100","author":"Javidiparsijani","year":"2021","journal-title":"Ear Nose Throat J"},{"key":"2024122611005344300_ref4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1017\/S0022215109004897","article-title":"A role for ipsilateral, selective neck dissection in carotid body tumours","volume":"123","author":"Morton","year":"2009","journal-title":"J Laryngol Otol"},{"key":"2024122611005344300_ref5","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1017\/S0022215111002994","article-title":"Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy","volume":"126","author":"Williamson","year":"2012","journal-title":"J Laryngol Otol"},{"key":"2024122611005344300_ref6","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.surg.2018.05.001","article-title":"A clinical prediction model to estimate the metastatic potential of pheochromocytoma\/paraganglioma: ASES score","volume":"164","author":"Cho","year":"2018","journal-title":"Surgery"},{"key":"2024122611005344300_ref7","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.jvs.2016.05.076","article-title":"Current surgical management of carotid body tumors","volume":"64","author":"Davila","year":"2016","journal-title":"J Vasc Surg"},{"key":"2024122611005344300_ref8","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/cncr.10252","article-title":"National Cancer Data Base report on malignant paragangliomas of the head and neck","volume":"94","author":"Lee","year":"2002","journal-title":"Cancer"},{"key":"2024122611005344300_ref9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1159\/000519046","article-title":"Necessity of intraoperative level IIA lymph node dissection in patients with carotid body Tumors: a retrospective study of 126 cases","volume":"84","author":"Ma","year":"2022","journal-title":"ORL J Otorhinolaryngol Relat Spec"}],"container-title":["Journal of Surgical Case 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