{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:38Z","timestamp":1753877198620,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Low anterior resection syndrome (LARS) is a challenging complication following sphincter-preserving rectal surgery, characterized by bowel dysfunctions such as urgency, frequency, and incontinence. This case series investigates the potential role of lactose intolerance in exacerbating LARS symptoms. Three patients who developed LARS after rectal resections showed persistent symptoms despite conventional management with bulking agents, physiotherapy, and loperamide. However, all three experienced significant improvement in symptomatology, reflected by reductions in their LARS scores, after eliminating cow\u2019s milk from their diets. These findings suggest a potential link between lactose intolerance, including possible late-onset forms, and LARS symptoms. This study highlights the effectiveness of dietary modifications, particularly lactose elimination, as a simple and non-invasive strategy for managing LARS. The findings also support the need for dietary screening processes and recommendations for milk substitutes to enhance clinical care. Further research is necessary to validate these observations and refine therapeutic strategies.<\/jats:p>","DOI":"10.1093\/jscr\/rjae850","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T18:16:02Z","timestamp":1737483362000},"source":"Crossref","is-referenced-by-count":0,"title":["Lactose free diet as therapeutic strategy in low anterior resection syndrome: a case series"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-3350","authenticated-orcid":false,"given":"Da W","family":"Thong","sequence":"first","affiliation":[{"name":"Department of General Surgery, Royal Perth Hospital , 197 Wellington Street, Perth, Western Australia 6000,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Theophilus","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Royal Perth Hospital , 197 Wellington Street, Perth, Western Australia 6000,","place":["Australia"]},{"name":"Department of General Surgery, St John of God Midland Public and Private Hospital , 1 Clayton Street, Midland, Western Australia 6056 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"2025012118155766100_ref1","doi-asserted-by":"publisher","first-page":"e403","DOI":"10.1016\/S1470-2045(12)70236-X","article-title":"Anterior resection syndrome","volume":"13","author":"Bryant","year":"2012","journal-title":"Lancet Oncol"},{"key":"2025012118155766100_ref2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/codi.13767","article-title":"Defining low anterior resection syndrome: a systematic review of the literature","volume":"19","author":"Keane","year":"2017","journal-title":"Colorectal 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