{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:39Z","timestamp":1753877199668,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gallbladder cancers (GBC) are insidious, malignant, and associated with poor prognosis, with a 5-year survival rate of 5%. Long-term survival in advanced GBC is rare. Here, we report a case of a 45-year-old female who presented with intermittent right upper quadrant pain for 1\u00a0month. A gallbladder mass and two liver masses were identified on a computed tomography (CT) scan of the abdomen and pelvis with intravenous contrast, which was highly suspicious for GBC. The patient underwent extended radical surgery, and a low to moderately differentiated gallbladder adenocarcinoma was diagnosed through pathology. Postoperatively, the patient received chemotherapy with gemcitabine and cisplatin but only tolerated one cycle. The patient has been disease-free for over 7\u00a0years, representing an unusually long survival.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf010","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T18:03:06Z","timestamp":1737396186000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term survival of stage 4 gallbladder cancer after extended radical surgery plus limited chemotherapy: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Zhengbin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hanchuan People\u2019s Hospital , 1 Renmin Avenue, Hanchuan, Hubei 431600 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hanchuan People\u2019s Hospital , 1 Renmin Avenue, Hanchuan, Hubei 431600 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hanchuan People\u2019s Hospital , 1 Renmin Avenue, Hanchuan, Hubei 431600 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hanchuan People\u2019s Hospital , 1 Renmin Avenue, Hanchuan, Hubei 431600 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hanchuan People\u2019s Hospital, 1 Renmin Avenue, Hanchuan, Hubei 431600 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6141-6550","authenticated-orcid":false,"given":"Zhengqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Winchester Medical Center , 1840 Amherst Street, Winchester, VA 22601 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"2025012018030035800_ref1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/CLEP.S37357","article-title":"Gallbladder cancer: epidemiology and outcome","volume":"6","author":"Hundal","year":"2014","journal-title":"Clin Epidemiol"},{"key":"2025012018030035800_ref2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s40792-018-0512-6","article-title":"Long-term survival of a patient with recurrent gallbladder carcinoma, treated with chemotherapy, immunotherapy, and surgery: a case report","volume":"4","author":"Kawamoto","year":"2018","journal-title":"Surgical Case Reports"},{"key":"2025012018030035800_ref3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s40792-017-0351-x","article-title":"Long-term survival after multidisciplinary therapy for residual gallbladder cancer with peritoneal dissemination: a case report","volume":"3","author":"Kuga","year":"2017","journal-title":"Surg Case Rep"},{"key":"2025012018030035800_ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40792-016-0135-8","article-title":"Long-term survival of a recurrent gallbladder carcinoma patient with lymph node and peritoneal metastases after multidisciplinary treatments: a case report","volume":"2","author":"Tomita","year":"2016","journal-title":"Surg Case Rep"},{"key":"2025012018030035800_ref5","first-page":"335","article-title":"Fourteen-years of disease-free survival in a patient with advanced gallbladder carcinoma after radical resection: a case report","volume":"56","author":"Watanabe","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"2025012018030035800_ref6","doi-asserted-by":"publisher","first-page":"4736","DOI":"10.3748\/wjg.v18.i34.4736","article-title":"\"Extended\" radical cholecystectomy for gallbladder cancer: long-term outcomes, indications and limitations","volume":"18","author":"Shirai","year":"2012","journal-title":"World J Gastroenterol"},{"key":"2025012018030035800_ref7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1148\/radiol.2018171187","article-title":"Imaging diagnosis of intrahepatic and perihilar cholangiocarcinoma: recent advances and challenges","volume":"288","author":"Joo","year":"2018","journal-title":"Radiology"},{"key":"2025012018030035800_ref8","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.4240\/wjgs.v14.i11.1272","article-title":"Assessment of tumor markers CA 19\u20139, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer","volume":"14","author":"Sinha","year":"2022","journal-title":"World J Gastrointest Surg"},{"key":"2025012018030035800_ref9","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3969\/j.issn.1001-5256.2016.04.031","article-title":"A prognostic analysis of laparoscopic versus radical cholecystectomy for T1b unsuspected gallbladder carcinoma","volume":"32","author":"WenLong","year":"2016","journal-title":"J Clin hepatology"},{"key":"2025012018030035800_ref10","doi-asserted-by":"publisher","first-page":"1186378","DOI":"10.3389\/fonc.2023.1186378","article-title":"Wedge resection versus segment IVb and V resection of the liver for T2 gallbladder cancer: a systematic review and meta-analysis","volume":"13","author":"Chen","year":"2023","journal-title":"Front Oncol"},{"key":"2025012018030035800_ref11","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1007\/s00464-024-11162-6","article-title":"Robotic, laparoscopic and open surgery for gallbladder cancer: a systematic review and network meta-analysis","volume":"38","author":"Chee","year":"2024","journal-title":"Surg Endosc"},{"key":"2025012018030035800_ref12","doi-asserted-by":"publisher","first-page":"7132","DOI":"10.3390\/curroncol30080517","article-title":"A practical guide for the systemic treatment of biliary tract cancer in Canada","volume":"30","author":"Ramjeesingh","year":"2023","journal-title":"Curr Oncol"},{"key":"2025012018030035800_ref13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13014-024-02481-y","article-title":"Clinical outcomes and risk stratification in unresectable biliary tract cancers undergoing radiation therapy","volume":"19","author":"Amit","year":"2024","journal-title":"Radiat Oncol"},{"key":"2025012018030035800_ref14","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/CM9.0000000000002759","article-title":"Advances in immunotherapy for biliary tract 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