{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:48:32Z","timestamp":1773283712677,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anal melanoma is a rare malignancy, accounting for 0.4% to 1.6% of all melanomas. Its atypical presentation, low incidence, and non-specific symptoms make it a challenging diagnosis, which can lead to delayed treatment with an unfavorable impact on clinical outcomes. Treatment should be multidisciplinary and may include surgical resection with adjuvant therapy, chemotherapy, and radiotherapy. We present the case of a male patient who presented to the emergency department due to foreign body sensation and transanal bleeding. The patient underwent an anal exploration under anesthesia, where a hyperpigmented canal-dependent tumor lesion with extension into the perianal skin was found. After a wide local excision, histopathological study confirmed the diagnosis of invasive nodular melanoma. The patient was discharged without complications for follow-up and management in the outpatient medical oncology clinic.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf015","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T15:41:56Z","timestamp":1737560516000},"source":"Crossref","is-referenced-by-count":3,"title":["Anal melanoma: a clinical challenge without therapeutic consensus"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-8290","authenticated-orcid":false,"given":"Kevin J","family":"Fuentes-Calvo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hospital M\u00e9dica Sur , Puente de Piedra 150, 140550 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-832X","authenticated-orcid":false,"given":"Francisco E","family":"Alvarez-Bautista","sequence":"additional","affiliation":[{"name":"Department of General and Endoscopic Surgery, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, 14080 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Santes","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , Vasco de Quiroga 15, 14080 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"De Nora-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital M\u00e9dica Sur , Puente de Piedra 150, 140550 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F","family":"Arias-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur , Puente de Piedra 150, 140550 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-5070","authenticated-orcid":false,"given":"Noel","family":"Salgado-Nesme","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , Vasco de Quiroga 15, 14080 Mexico City ,","place":["Mexico"]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico , Avenida Universidad 3000, 04510 Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"2025012215414182200_ref1","doi-asserted-by":"publisher","first-page":"e2770","DOI":"10.1097\/MD.0000000000002770","article-title":"Incidence, surgical treatment, and prognosis of anorectal melanoma from 1973 to 2011: a population-based SEER 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