{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:31:18Z","timestamp":1788787878807,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute upper airway obstruction (AUAO) due to benign thyroid disease is a rare but life-threatening condition. We report a case of an 82-year-old woman with a toxic multinodular goitre who presented to the emergency department with confusion and noisy breathing. Despite being initially stable, she developed progressive stridor and hypoxemia. A neck CT revealed significant tracheal compression due to the goitre. Immediate intubation and corticosteroid treatment were followed by urgent total thyroidectomy and tracheostomy. She was admitted to the ICU for management of laryngeal oedema and rehabilitation. The pathophysiology of AUAO in benign goitres is multifactorial, involving potential haemorrhage, infection, or exacerbation of comorbid respiratory conditions. Early diagnosis through imaging and prompt intervention with thyroidectomy is crucial for survival. Postoperative monitoring for complications like laryngeal oedema and tracheomalacia is essential. This case emphasizes the need for vigilance in managing airway compromise in patients with large multinodular goitres.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf105","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T22:19:31Z","timestamp":1741126771000},"source":"Crossref","is-referenced-by-count":1,"title":["Multinodular benign goitre as an immediate threat to the airway: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-8882","authenticated-orcid":false,"given":"Andreia J","family":"Santos","sequence":"first","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-8512","authenticated-orcid":false,"given":"Jo\u00e3o Lu\u00eds","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-4653","authenticated-orcid":false,"given":"Daniela","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Unidade Local de Sa\u00fade Viseu D\u00e3o-Laf\u00f5es , Avenida Rei Dom Duarte, 3504-509, Viseu,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"2025030422192209300_ref1","volume-title":"Upper Airway Obstruction. The ACP Manual of Critical Care Medicine","author":"Yataco","year":"2008"},{"key":"2025030422192209300_ref2","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1445-2197.2007.04061.x","article-title":"Benign nodular goitre presenting as acute airway obstruction","volume":"77","author":"Abraham","year":"2007","journal-title":"ANZ J Surg"},{"key":"2025030422192209300_ref3","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1089\/thy.2020.0944","article-title":"2021 American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer","volume":"31","author":"Bible","year":"2021","journal-title":"Thyroid"},{"key":"2025030422192209300_ref4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/hed.23857","article-title":"Management of the compromised airway and role of tracheotomy in anaplastic thyroid carcinoma","volume":"38","author":"Mani","year":"2016","journal-title":"Head Neck"},{"key":"2025030422192209300_ref5","doi-asserted-by":"publisher","first-page":"e228095","DOI":"10.1136\/bcr-2018-228095","article-title":"Acute airway obstruction due to benign multinodular goitre","volume":"12","author":"Dias","year":"2019","journal-title":"BMJ Case Reports CP"},{"key":"2025030422192209300_ref6","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1017\/S0022215106003045","article-title":"Management of life-threatening airway obstruction caused by benign thyroid disease","volume":"120","author":"Kadhim","year":"2006","journal-title":"J Laryngol Otol"},{"key":"2025030422192209300_ref7","doi-asserted-by":"publisher","first-page":"S127","DOI":"10.4103\/2230-8210.83351","article-title":"Prevalence of upper airway obstruction in patients with apparently asymptomatic euthyroid multi nodular goitre","volume":"15","author":"Menon","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"2025030422192209300_ref8","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.21037\/gs-20-859","article-title":"Narrative review of management of thyroid surgery complications","volume":"10","author":"Jin","year":"2021","journal-title":"Gland Surg"},{"key":"2025030422192209300_ref9","volume-title":"Diagn\u00f3stico, Terap\u00eautica e Seguimento do Cancro Diferenciado da Tir\u00f3ide, Cap\u00edtulo de Cirurgia End\u00f3crina da Sociedade Portuguesa de Cirurgia","author":"Costa","year":"2013"},{"key":"2025030422192209300_ref10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/anae.15585","article-title":"Management of haematoma after thyroid surgery: systematic review and multidisciplinary consensus guidelines from the difficult airway society, the British Association of Endocrine and Thyroid Surgeons and the British Association of Otorhinolaryngology, head and neck surgery","volume":"77","author":"Iliff","year":"2022","journal-title":"Anaesthesia"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/2\/rjaf105\/62206910\/rjaf105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/2\/rjaf105\/62206910\/rjaf105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T22:19:34Z","timestamp":1741126774000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf105\/8046278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf105","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2]]},"article-number":"rjaf105"}}