{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:32:03Z","timestamp":1791955923623,"version":"4.3.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA0946"],"award-info":[{"award-number":["23JRRA0946"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report a rare case of severe acute pancreatitis with hypercalcaemia induced by primary hyperparathyroidism (PHPT) in a 27-year-old female patient at 28\u00a0weeks of gestation during pregnancy. The patient initially presented with onset epigastric pain with nausea and vomiting and was diagnosed with severe acute pancreatitis, hypercalcaemia, and PHPT. After conservative management, the patient underwent a caesarean section and successfully delivered a baby boy, who suffered from hypocalcaemic convulsions in the postnatal period. The patient\u2019s blood calcium level was still elevated and subsequently diagnosed as a left parathyroid adenoma by single photon emission computed tomography, and her blood calcium returned to normal after parathyroidectomy. PHPT in pregnancy is often difficult to diagnose early because of the non-specific clinical manifestations. Early recognition and timely surgical treatment are crucial for the safety of the mother and baby. In patients with PHPT with moderate to severe hypercalcaemia, parathyroidectomy is recommended in mid-pregnancy.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf161","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:38:51Z","timestamp":1743439131000},"source":"Crossref","is-referenced-by-count":2,"title":["Severe acute pancreatitis induced by primary hyperparathyroidism in pregnancy: a case report and literature review"],"prefix":"10.1093","volume":"2025","author":[{"given":"Xusheng","family":"Liu","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , No. 11, Donggang West Road, Chengguan District, Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"General Surgery Department, The First Hospital of Lanzhou University , No. 11, Donggang West Road, Chengguan District, Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , No. 11, Donggang West Road, Chengguan District, Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5011-793X","authenticated-orcid":false,"given":"Shengbing","family":"Zhao","sequence":"additional","affiliation":[{"name":"General Surgery Department, The First Hospital of Lanzhou University , No. 11, Donggang West Road, Chengguan District, Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025040114580867400_ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132956","article-title":"Primary hyperparathyroidism in pregnancy: literature review of the diagnosis and management","volume":"10","author":"Ali","year":"2021","journal-title":"J Clin Med"},{"key":"2025040114580867400_ref2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/09513590.2019.1698028","article-title":"Primary hyperparathyroidism presenting as severe hypercalcemia with acute pancreatitis in pregnancy","volume":"36","author":"Bansal","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2025040114580867400_ref3","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jama.2022.18331","article-title":"Hypercalcemia: a review","volume":"328","author":"Walker","year":"2022","journal-title":"JAMA"},{"key":"2025040114580867400_ref4","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1089\/jwh.2009.1777","article-title":"Primary hyperparathyroidism in pregnancy: a diagnostic and therapeutic challenge","volume":"19","author":"Nilsson","year":"2010","journal-title":"J Womens Health (Larchmt)"},{"key":"2025040114580867400_ref5","first-page":"104832","article-title":"Acute pancreatitis secondary to hypercalcemia in a patient with primary hyperparathyroidism: an uncommon association","volume":"2022","author":"Arhoun El Haddad","year":"2012","journal-title":"Ann Med Surg (Lond)"},{"key":"2025040114580867400_ref6","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.ecl.2011.08.002","article-title":"Calcium and bone metabolism disorders during pregnancy and lactation","volume":"40","author":"Kovacs","year":"2011","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025040114580867400_ref7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.51821\/84.2.367","article-title":"Hypercalcemia induced pancreatitis as a rare presentation of primary hyperparathyroidism","volume":"84","author":"Desmedt","year":"2021","journal-title":"Acta Gastroenterol Belg"},{"key":"2025040114580867400_ref8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/BF02787530","article-title":"Primary hyperparathyroidism and acute pancreatitis during pregnancy. Report of a case and a review of the English and Japanese literature","volume":"24","author":"Kondo","year":"1998","journal-title":"Int J Pancreatol"},{"key":"2025040114580867400_ref9","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1471-2393-13-130","article-title":"Is minimally invasive parathyroid surgery an option for patients with gestational primary hyperparathyroidism?","volume":"13","author":"Bendinelli","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025040114580867400_ref10","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1148\/rg.285075055","article-title":"Parathyroid scintigraphy in patients with primary hyperparathyroidism: 99mTc sestamibi SPECT and SPECT\/CT","volume":"28","author":"Eslamy","year":"2008","journal-title":"Radiographics"},{"key":"2025040114580867400_ref11","doi-asserted-by":"publisher","first-page":"e25451","DOI":"10.1097\/MD.0000000000025451","article-title":"Hyperparathyroidism presenting as hyperemesis and acute pancreatitis in pregnancy: a case report","volume":"100","author":"Tsai","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"2025040114580867400_ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","article-title":"Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus","volume":"28","author":"Khan","year":"2017","journal-title":"Osteoporosis Int"},{"key":"2025040114580867400_ref13","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1210\/clinem\/dgac734","article-title":"Approach to the patient: Management of parathyroid diseases across pregnancy","volume":"108","author":"Appelman-Dijkstra","year":"2023","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/4\/rjaf161\/62791157\/rjaf161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/4\/rjaf161\/62791157\/rjaf161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T16:36:34Z","timestamp":1743525394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf161\/8098721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf161","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,28]]},"article-number":"rjaf161"}}