{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:07:24Z","timestamp":1768586844437,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cryobiopsy offers an advantage because of the extraction of more extensive tissue and enhanced diagnostic accuracy. However, the risk of bleeding from the biopsy site is higher. We report a lung tumor patient who experienced bleeding in the right main bronchus after cryobiopsy. Suctioning was performed, cold saline was administered, and the bleeding stopped. Five minutes after the procedure, the patient experienced desaturation. A re-bronchoscopy found massive bleeding in the right main bronchus which spread to the left main bronchus. Suctioning was performed, cold saline and epinephrine were administered. Before further treatment was given, the patient got cardiac arrest and he was treated in the intensive care unit. This highlighted the importance of training and considering the additional precautions for bleeding control. Intensive monitoring of the patients is needed when performing cryobiopsy to prepare for the early management of complications, especially for those patients with risk factors for bleeding in cryobiopsy.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf231","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:47:01Z","timestamp":1745038021000},"source":"Crossref","is-referenced-by-count":1,"title":["Fatal airway obstruction due to endobronchial bleeding post cryobiopsy: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Muhammad","family":"Nadzir","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University \u2013 Dr. Soetomo General Academic Hospital , Jl. Mayjen Prof. Dr. Moesto po No. 6-8, Surabaya 60286 ,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isnin Anang","family":"Marhana","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University \u2013 Dr. Soetomo General Academic Hospital , Jl. Mayjen Prof. Dr. Moesto po No. 6-8, Surabaya 60286 ,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Fatmawati","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University \u2013 Dr. Soetomo General Academic Hospital , Jl. Mayjen Prof. Dr. Moesto po No. 6-8, Surabaya 60286 ,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"2025041900464623900_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/medicina57040393","article-title":"Cryobiopsy in lung cancer diagnosis\u2014a literature review","volume":"57","author":"Simon","year":"2021","journal-title":"Medicine"},{"key":"2025041900464623900_ref2","doi-asserted-by":"publisher","first-page":"106922","DOI":"10.1016\/j.rmed.2022.106922","article-title":"Risk factors of clinically significant complications in transbronchial lung cryobiopsy: a prospective multi-center study","volume":"2022","author":"Mononen","year":"2021","journal-title":"Respir Med"},{"key":"2025041900464623900_ref3","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.21037\/jtd.2019.04.59","article-title":"Novel technique to prevent central airway blood flooding during transbronchial cryobiopsy","volume":"11","author":"Oki","year":"2019","journal-title":"J Thorac Dis"},{"key":"2025041900464623900_ref4","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1513\/AnnalsATS.201701-046CC","article-title":"Sequential bronchoscopic cryobiopsy and cryotherapy","volume":"14","author":"Benninger","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"2025041900464623900_ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12931-019-1091-1","article-title":"Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease - a prospective, randomized, multicentre cross-over trial","volume":"20","author":"Hetzel","year":"2019","journal-title":"Respir Res"},{"key":"2025041900464623900_ref6","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1513\/AnnalsATS.201610-829OC","article-title":"High complication rate after introduction of transbronchial cryobiopsy into clinical practice at an academic medical center","volume":"14","author":"DiBardino","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"2025041900464623900_ref7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.5603\/ARM.2017.0052","article-title":"Cryobiopsy versus forceps biopsy in endobronchial lesions, diagnostic yield and safety","volume":"85","author":"Ehab","year":"2017","journal-title":"Adv Respir Med"},{"key":"2025041900464623900_ref8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.4103\/1817-1737.69117","article-title":"Endobronchial cryobiopsy or forceps biopsy for lung cancer diagnosis","volume":"5","author":"Aktas","year":"2010","journal-title":"Ann Thorac Med"},{"key":"2025041900464623900_ref9","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s00464-016-5095-3","article-title":"How many samples would be optimal for endobronchial cryobiopsy?","volume":"31","author":"Segmen","year":"2017","journal-title":"Surg Endosc"},{"key":"2025041900464623900_ref10","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00084-2016","article-title":"Iatrogenic bleeding during flexible bronchoscopy: risk factors, prophylactic measures and management","volume":"3","author":"Bernasconi","year":"2017","journal-title":"ERJ Open Res"},{"key":"2025041900464623900_ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12890-021-01817-8","article-title":"Safety profile and risk factors for bleeding in transbronchial cryobiopsy using a two-scope technique for peripheral pulmonary lesions","volume":"22","author":"Nakai","year":"2022","journal-title":"BMC Pulm Med"},{"key":"2025041900464623900_ref12","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.chest.2022.10.013","article-title":"Tranexamic acid vs adrenaline for controlling iatrogenic bleeding during flexible bronchoscopy","volume":"163","author":"Badovinac","year":"2023","journal-title":"Chest"},{"key":"2025041900464623900_ref13","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1183\/09031936.94.07112033","article-title":"Three years of experience with a new balloon catheter for the management of haemoptysis","volume":"7","author":"Freitag","year":"1994","journal-title":"Eur Respir J"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/4\/rjaf231\/62955907\/rjaf231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/4\/rjaf231\/62955907\/rjaf231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:47:02Z","timestamp":1745038022000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf231\/8116341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf231","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,29]]},"article-number":"rjaf231"}}