{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T03:59:12Z","timestamp":1754193552834,"version":"3.41.2"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Toxic megacolon is a potentially lethal disease process in which there is a non-mechanical dilation of the colon to &amp;gt;6 cm, often associated with systemic effects including leukocytosis or hemodynamic compromise. Here, we present a case of a 49-year-old male who presented with idiopathic toxic megacolon who underwent a subtotal colectomy with end ileostomy. Pathology confirmed no inflammatory bowel disease or Clostridium difficile infection, the most common etiologies. This was a unique case in that the patient did not present with the most common etiology, but did have a history of chronic constipation in the setting of antipsychotic\/antidepressant use. Scattered cases of antipsychotic-induced toxic megacolon have been described in the literature, but to the author\u2019s knowledge, none related to aripiprazole or clomipramine. This case highlights the importance of diligent clinical monitoring for patients on psychiatric medications.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf265","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T03:03:08Z","timestamp":1751166188000},"source":"Crossref","is-referenced-by-count":1,"title":["A novel case of aripiprazole and clomipramine-induced toxic megacolon: enough to drive anyone mad"],"prefix":"10.1093","volume":"2025","author":[{"given":"Taylor J","family":"Casey","sequence":"first","affiliation":[{"name":"Department of General Surgery, UPMC Harrisburg , 111 S Front Street, Harrisburg, PA 17101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britton P","family":"Mehr","sequence":"additional","affiliation":[{"name":"Department of General Surgery, UPMC Harrisburg , 111 S Front Street, Harrisburg, PA 17101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"2025062823030451900_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae200","article-title":"Toxic megacolon","volume":"111","author":"Argyriou","year":"2024","journal-title":"Br J Surg"},{"key":"2025062823030451900_ref2","doi-asserted-by":"publisher","first-page":"rjae403","DOI":"10.1093\/jscr\/rjae403","article-title":"Toxic megacolon: a potentially lethal condition. Case report","volume":"2024","author":"Fabi\u00e1n-M\u00e9ndez","year":"2024","journal-title":"J Surg Case Rep"},{"key":"2025062823030451900_ref3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1201\/9781003523017-5","volume-title":"Clinical Challenges and Complications of IBD","author":"Cullen","year":"2024"},{"key":"2025062823030451900_ref4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2147\/CEG.S200760","article-title":"Toxic megacolon: background, pathophysiology, management challenges and solutions","volume":"13","author":"Desai","year":"2020","journal-title":"Clin Exp Gastroenterol"},{"key":"2025062823030451900_ref5","first-page":"100691","volume-title":"Seminars in Colon and Rectal Surgery","author":"Anderson","year":"2019"},{"key":"2025062823030451900_ref6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.22516\/25007440.256","article-title":"Megacolon toxic of idiophatic origin: case report","volume":"33","author":"Siado","year":"2018","journal-title":"Revista colombiana de Gastroenterolog\u00eda"},{"key":"2025062823030451900_ref7","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/978-3-031-22599-4_83","volume-title":"Textbook of Emergency General Surgery: Traumatic and Non-traumatic Surgical","author":"Marwah","year":"2023"},{"key":"2025062823030451900_ref8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.36348\/sjmps.2020.v06i01.010","article-title":"Toxic megacolon with colonic ischemia masquerading as diabetic ketoacidosis: a case report","volume":"6","author":"Mansouri","year":"2020","journal-title":"Saudi J Med Pharm Sci"},{"key":"2025062823030451900_ref9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1192\/bjp.2022.24","article-title":"Clozapine-induced gastrointestinal hypomotility: presenting features and outcomes, UK pharmacovigilance reports, 1992\u20132017","volume":"220","author":"Handley","year":"2022","journal-title":"Br J Psychiatry"},{"key":"2025062823030451900_ref10","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1002\/pds.1801","article-title":"Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database","volume":"18","author":"Peyri\u00e8re","year":"2009","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2025062823030451900_ref11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s40263-021-00859-0","article-title":"Antipsychotic-induced constipation: a review of the pathogenesis, clinical diagnosis, and treatment","volume":"35","author":"Xu","year":"2021","journal-title":"CNS Drugs"},{"key":"2025062823030451900_ref12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/YIC.0000000000000331","article-title":"Challenges associated with treating and preventing antipsychotic-induced constipation: considerations and cautions when prescribing novel interventions","volume":"36","author":"Demler","year":"2021","journal-title":"Int Clin Psychopharmacol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf265\/63561660\/rjaf265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf265\/63561660\/rjaf265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T03:03:10Z","timestamp":1751166190000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf265\/8172116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf265","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,31]]},"article-number":"rjaf265"}}