{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:41Z","timestamp":1753877261455,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A man in his thirties with congenital indifference to pain with anosmia (CIP) presented to a tertiary centre for an elective biopsy and video-assisted thoracoscopic surgery. Intra-operatively, he demonstrated no autonomic reflex in response to intubation or surgical stimulus, out of keeping with similar case reports in the medical literature. Post-operatively, he developed intermittent tachycardia, hypertension and pyrexia, which was controlled with opioid and non-opioid-based analgesics. Post-operative pyrexia and tachycardia alerted the patient to a developing chest infection, resulting in re-admission. Learning points include the importance of regular and accurate national early warning score documentation in patients with CIP, and the utility of conventional analgesia in tempering the autonomic response to stress in this patient group.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf275","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T20:35:24Z","timestamp":1746304524000},"source":"Crossref","is-referenced-by-count":0,"title":["Post-operative analgesic regime in a patient with congenital indifference to pain"],"prefix":"10.1093","volume":"2025","author":[{"given":"Thomas","family":"French","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery , Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeet Singh","family":"Avtaar Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery , Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh,","place":["United Kingdom"]},{"name":"School of Cardiovascular and Metabolic Health , University of Glasgow, 126 University Place, G12 8TA,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Coley","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Royal Infirmary of Edinburgh , Little France Crescent, EH16 4SA, Edinburgh,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Will","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery , Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"2025050316351859800_ref1","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1172\/JCI33297","article-title":"Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders","volume":"117","author":"Drenth","year":"2007","journal-title":"J Clin Invest"},{"key":"2025050316351859800_ref2","doi-asserted-by":"publisher","first-page":"12706","DOI":"10.1073\/pnas.0404915101","article-title":"Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain","volume":"101","author":"Nassar","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025050316351859800_ref3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1744-8069-7-32","article-title":"Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons","volume":"7","author":"Ahn","year":"2011","journal-title":"Mol Pain"},{"key":"2025050316351859800_ref4","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"volume-title":"Hereditary Sensory and Autonomic Neuropathy Type II. Adam MP, Feldman J, Mirzaa GM, et\u00a0al, editors GeneReviews\u00ae [Internet]","year":"2021","author":"Kurth","key":"2025050316351859800_ref5"},{"key":"2025050316351859800_ref6","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/00005053-193206000-00002","article-title":"A case of congenital general pure analgesia","volume":"75","author":"GvN","year":"1932","journal-title":"Journal of Nervous and Mental Disease"},{"key":"2025050316351859800_ref7","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1213\/ANE.0000000000000912","article-title":"Anesthetic Management of Patients with congenital insensitivity to pain with anhidrosis: a retrospective analysis of 358 procedures performed under general anesthesia","volume":"121","author":"Zlotnik","year":"2015","journal-title":"Anesth Analg"},{"key":"2025050316351859800_ref8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1046\/j.1460-9592.2003.01235.x","article-title":"The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis","volume":"14","author":"Rozentsveig","year":"2004","journal-title":"Paediatr Anaesth"},{"key":"2025050316351859800_ref9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13256-017-1406-0","article-title":"Anesthetic management during adenotonsillectomy for twins with congenital insensitivity to pain with anhidrosis: two case reports","volume":"11","author":"Wang","year":"2017","journal-title":"J Med Case Reports"},{"key":"2025050316351859800_ref10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1272\/jnms.84.237","article-title":"Anesthesia procedure for congenital insensitivity to pain in a child with anhidrosis syndrome: a rare case","volume":"84","author":"Urfalioglu","year":"2017","journal-title":"J Nippon Med Sch"},{"key":"2025050316351859800_ref11","first-page":"395","article-title":"Anaesthesia for congenital analgesia","volume":"41","author":"Layman","year":"1986","journal-title":"A Case Rep Anaesth"},{"key":"2025050316351859800_ref12","doi-asserted-by":"publisher","first-page":"202","DOI":"10.14744\/agri.2019.91297","article-title":"Anesthetic management of two siblings with congenital insensitivity to pain with anhidrosis syndrome","volume":"31","author":"Destegul","year":"2019","journal-title":"Agri"},{"key":"2025050316351859800_ref13","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/S0034-7094(09)70085-6","article-title":"Anesthesia in a patient with congenital insensitivity to pain and anhidrosis","volume":"59","author":"Oliveira","year":"2009","journal-title":"Rev Bras Anestesiol"},{"key":"2025050316351859800_ref14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1046\/j.1460-9592.2000.00542.x","article-title":"Anaesthetic management of children with congenital insensitivity to pain with anhidrosis","volume":"10","author":"Okuda","year":"2000","journal-title":"Paediatr Anaesth"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/5\/rjaf275\/63051553\/rjaf275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/5\/rjaf275\/63051553\/rjaf275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T20:35:25Z","timestamp":1746304525000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf275\/8124672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf275","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,29]]},"article-number":"rjaf275"}}