{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:27Z","timestamp":1753877247887,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-grade serous ovarian carcinoma (HGSOC) typically spreads within the peritoneal cavity, and metastatic spread to extraperitoneal lymph nodes, particularly the inguinal region, is rare. Herein, we present a case of a 47-year-old premenopausal woman who presented with an enlarging, ulcerating right inguinal mass. Imaging revealed a necrotic inguinal mass, with no significant intra-abdominal findings. Surgical excision was performed, and histopathology confirmed metastatic HGSOC. She then underwent neoadjuvant chemotherapy, followed by radiotherapy. She then underwent robotic-surgical staging. Histopathological analysis showed bilateral ovarian involvement with multiple tumor foci. Genetic testing identified a BRCA1 mutation, leading to adjuvant maintenance therapy with Olaparib. This case emphasizes the importance of considering ovarian carcinoma in the differential diagnosis of unusual inguinal lymph node masses, even without a visible ovarian mass. Early detection, genetic testing, and a multidisciplinary approach are essential for optimizing patient outcomes in advanced HGSOC with atypical metastasis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf317","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T12:16:18Z","timestamp":1747829778000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare presentation of high-grade serous ovarian carcinoma with ulcerating inguinal lymph node metastasis: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Hassan M","family":"Latifah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , King Faisal Specialist Hospital and Research Center, Jeddah 23433,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzanah","family":"Almarzugi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , King Faisal Specialist Hospital and Research Center, Jeddah 23433,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Bitar","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal Specialist Hospital and Research Center ,","place":["Jeddah 23433, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alyafi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University , Jeddah 22254 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik","family":"Abumohssin","sequence":"additional","affiliation":[{"name":"Department of Radiology, King Faisal Specialist Hospital and Research Center ,","place":["Jeddah 23433, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhoor","family":"Almansouri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center ,","place":["Jeddah 23433, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool Abdulaziz","family":"Kabli","sequence":"additional","affiliation":[{"name":"College of Medicine, Umm Al-Qura University ,","place":["Makkah 21955, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusaybah A","family":"Shafi","sequence":"additional","affiliation":[{"name":"College of Medicine, Umm Al-Qura University ,","place":["Makkah 21955, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-8758","authenticated-orcid":false,"given":"Saeed","family":"Baradwan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center , Jeddah 23433,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"2025052108161301600_ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213777","article-title":"Molecular Management of high-grade serous ovarian carcinoma","volume":"23","author":"Punzon-Jimenez","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025052108161301600_ref2","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.ccell.2024.08.016","article-title":"Ovarian cancer metastasis: looking beyond the surface","volume":"42","author":"Bayraktar","year":"2024","journal-title":"Cancer Cell"},{"key":"2025052108161301600_ref3","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.7150\/jca.88863","article-title":"Inguinal lymph node metastasis as sole manifestation of ovarian\/fallopian tube cancer: a review of the literature","volume":"14","author":"Stavros","year":"2023","journal-title":"J Cancer"},{"key":"2025052108161301600_ref4","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/1097-0142(197803)41:3&lt;919::AID-CNCR2820410320&gt;3.0.CO;2-A","article-title":"Inguinal node metastases","volume":"41","author":"Zaren","year":"1978","journal-title":"Cancer"},{"key":"2025052108161301600_ref5","doi-asserted-by":"publisher","first-page":"104603","DOI":"10.1016\/j.critrevonc.2024.104603","article-title":"The multiple facets of ovarian high grade serous carcinoma: a review on morphological, immunohistochemical and molecular features","volume":"208","author":"Santoro","year":"2025","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025052108161301600_ref6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/ijgo.12614","article-title":"Cancer of the ovary, fallopian tube, and peritoneum","volume":"143","author":"Berek","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"2025052108161301600_ref7","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ygyno.2018.06.022","article-title":"Sites of distant metastases and overall survival in ovarian cancer: a study of 1481 patients","volume":"150","author":"Deng","year":"2018","journal-title":"Gynecol Oncol"},{"key":"2025052108161301600_ref8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ygyno.2017.07.124","article-title":"Should epithelial ovarian carcinoma metastatic to the inguinal lymph nodes be assigned stage IVB?","volume":"147","author":"Nasioudis","year":"2017","journal-title":"Gynecol Oncol"},{"key":"2025052108161301600_ref9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/0284186X.2017.1400691","article-title":"Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease - a Swedish Gynecologic Cancer Group (SweGCG) study","volume":"57","author":"Hjerpe","year":"2018","journal-title":"Acta Oncologica (Stockholm, Sweden)"},{"key":"2025052108161301600_ref10","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s11523-021-00842-1","article-title":"Olaparib: a review as first-line maintenance therapy in advanced ovarian cancer","volume":"16","author":"Paik","year":"2021","journal-title":"Target Oncol"},{"key":"2025052108161301600_ref11","doi-asserted-by":"publisher","first-page":"CD007929","DOI":"10.1002\/14651858.CD007929.pub4","article-title":"Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer","volume":"2","author":"Tattersall","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"2025052108161301600_ref12","doi-asserted-by":"publisher","first-page":"CD012007","DOI":"10.1002\/14651858.CD012007.pub2","article-title":"Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with epithelial ovarian cancer","volume":"2","author":"Ngoi","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"2025052108161301600_ref13","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11172413","article-title":"Is it time to reassess the role of radiotherapy treatment in ovarian cancer?","volume":"11","author":"Macchia","year":"2023","journal-title":"Healthcare (Basel)"},{"key":"2025052108161301600_ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041422","article-title":"Risk-reducing breast and gynecological surgery for BRCA mutation carriers: a narrative review","volume":"12","author":"Bertozzi","year":"2023","journal-title":"J Clin Med"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/5\/rjaf317\/63262126\/rjaf317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/5\/rjaf317\/63262126\/rjaf317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T12:16:19Z","timestamp":1747829779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf317\/8139858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf317","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,29]]},"article-number":"rjaf317"}}