{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:59Z","timestamp":1753877219156,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with familial adenomatous polyposis (FAP) or ulcerative colitis (UC) are at increased risk of colorectal cancer (CRC), making surgical decision-making complex. This case series reviews six patients with FAP or UC who developed CRC and underwent ileal pouch-anal anastomosis (IPAA). Two patients with stage III CRC developed metastases, while the remaining four with stage I\/II had no recurrence. IPAA is feasible in stage I\/II CRC regardless of tumor location. For stage III colon cancer, total proctocolectomy (TPC) with IPAA followed by adjuvant chemotherapy is appropriate. In stage III rectal cancer more than 2\u00a0cm from the dentate line, IPAA can follow total neoadjuvant treatment (TNT). For tumors within 2\u00a0cm of the dentate line, TPC with end ileostomy is advised. IPAA may be contraindicated in cases with severe proctitis due to bleeding risk or radiation intolerance. Overall, IPAA is a suitable option for selected FAP or UC patients with CRC.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf332","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T07:38:37Z","timestamp":1747899517000},"source":"Crossref","is-referenced-by-count":0,"title":["Ileal pouch-anal anastomosis in familial adenomatous polyposis and ulcerative colitis with coexisting colorectal cancer: a guideline for treatment"],"prefix":"10.1093","volume":"2025","author":[{"given":"Mohammed","family":"Aldakhil","sequence":"first","affiliation":[{"name":"Surgery Department, College of Medicine , Qassim University, Al\u2019Qassim-","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-5942","authenticated-orcid":false,"given":"Nasser","family":"Alsanea","sequence":"additional","affiliation":[{"name":"Surgery Department, College of Medicine, Princess Nourah Bint Abdulrahman University , Riyadh 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