{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:00Z","timestamp":1753877220946,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive sarcomas, often affecting the head and neck, with higher incidence in neurofibromatosis type 1. Early diagnosis is crucial to prevent recurrence and metastasis. We report a 78-year-old male with a rapidly enlarging right nasal cavity mass over 4\u00a0months, associated with recurrent epistaxis. His medical history included diabetes, hypertension, and tobacco use. Examination revealed a firm, non-adherent mass obstructing the nasal cavity. Computed tomography (CT) imaging localized it to the right inferior turbinate. Due to size and location, biopsy was not performed. Surgical resection confirmed a high-grade MPNST (FNCLCC grade 3). Chemotherapy was initiated postoperatively, but the patient passed away soon after, highlighting the tumor\u2019s aggressiveness. MPNSTs should be considered in nasal mass differentials, especially in elderly smokers. Early surgery and chemotherapy may improve outcomes, emphasizing the need for a multidisciplinary approach.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf349","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T03:54:46Z","timestamp":1748577286000},"source":"Crossref","is-referenced-by-count":0,"title":["Malignant peripheral nerve sheath tumor of the nasal cavity: a rare diagnostic and therapeutic challenge"],"prefix":"10.1093","volume":"2025","author":[{"given":"Amine","family":"Oussalem","sequence":"first","affiliation":[{"name":"Department of Maxillo-Facial Surgery, Avicenne Hospital , Area Lamfadel Cherkaoui Rabat \u2013 Institut, Rabat BP 6527 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Azgaoui","sequence":"additional","affiliation":[{"name":"Department of Maxillo-Facial Surgery, Avicenne Hospital , Area Lamfadel Cherkaoui Rabat \u2013 Institut, Rabat BP 6527 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouchra","family":"Dani","sequence":"additional","affiliation":[{"name":"Department of Maxillo-Facial Surgery, Avicenne Hospital , Area Lamfadel Cherkaoui Rabat \u2013 Institut, Rabat BP 6527 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik","family":"Boulaadas","sequence":"additional","affiliation":[{"name":"Department of Maxillo-Facial Surgery, Avicenne Hospital , Area Lamfadel Cherkaoui Rabat \u2013 Institut, Rabat BP 6527 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"2025052923544305400_ref1","doi-asserted-by":"publisher","first-page":"i40","DOI":"10.1093\/noajnl\/vdz047","article-title":"Diagnosis and management of malignant peripheral nerve sheath tumors: current practice and future 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immunohistochemistry","volume":"69","author":"Chahal","year":"2017","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2025052923544305400_ref8","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1097\/MPH.0000000000000524","article-title":"Malignant peripheral nerve sheath tumors: clinical and radiographic features","volume":"38","author":"Spunt","year":"2016","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025052923544305400_ref9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/jclinpath-2017-203504","article-title":"Peripheral nerve sheath tumors: a diagnostic challenge in the paranasal sinuses","volume":"71","author":"Fern\u00e1ndez-Robles","year":"2018","journal-title":"J Clin Pathol"},{"key":"2025052923544305400_ref10","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/jso.25673","article-title":"Malignant peripheral nerve sheath tumors: review of 60 cases from a single 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