{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:17:42Z","timestamp":1756253862246,"version":"3.44.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Caroli's disease is a rare congenital disorder characterized by cystic dilatations of the intrahepatic bile ducts, often leading to recurrent bacterial cholangitis, biliary lithiasis, and cirrhosis. In 7%\u201316% of cases, it progresses to intrahepatic cholangiocarcinoma, emphasizing the need for early diagnosis and intervention. This report presents a 56-year-old patient with recurrent upper abdominal pain, chronic fatigue, and night sweats. Imaging studies (computed tomography, endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography) revealed dilated bile ducts and a hypodense lesion in the left hepatic lobe, prompting a left hemihepatectomy. Histopathological analysis confirmed a 12\u00a0cm mucinous, papillary cholangiocarcinoma. Postoperative follow-up showed no recurrence or metastasis. Treatment strategies depend on disease extent, with surgical resection being the preferred approach for localized disease, while liver transplantation remains the only curative option for bilateral involvement.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf380","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:52:25Z","timestamp":1749801145000},"source":"Crossref","is-referenced-by-count":0,"title":["Management of intrahepatic cholangiocarcinoma in a patient with Caroli's disease: a case report and literature review"],"prefix":"10.1093","volume":"2025","author":[{"given":"Omar","family":"Abouelwafa","sequence":"first","affiliation":[{"name":"Department of Surgery (A), Heinrich-Heine-University, Medical Faculty and University Hospital Duesseldorf , Moorenstr. 5, 40225 Duesseldorf, North Rhine-Westphalia ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Lehwald-Tywuschik","sequence":"additional","affiliation":[{"name":"Department of Surgery, AKH Viersen , Hoserkirchweg 63, 41747 Viersen, North Rhine-Westphalia ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Prassas","sequence":"additional","affiliation":[{"name":"Department of Surgery (A), Heinrich-Heine-University, Medical Faculty and University Hospital Duesseldorf , Moorenstr. 5, 40225 Duesseldorf, North Rhine-Westphalia ,","place":["Germany"]},{"name":"Department of Surgery, Katholisches Klinikum Essen, Philippusstift, Teaching Hospital of Duisburg-Essen University , Huelsmannstr, 17, 45355 Essen, North Rhine-Westphalia ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram Trudo","family":"Knoefel","sequence":"additional","affiliation":[{"name":"Department of Surgery (A), Heinrich-Heine-University, Medical Faculty and University Hospital Duesseldorf , Moorenstr. 5, 40225 Duesseldorf, North Rhine-Westphalia ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Vaghiri","sequence":"additional","affiliation":[{"name":"Department of Surgery (A), Heinrich-Heine-University, Medical Faculty and University Hospital Duesseldorf , Moorenstr. 5, 40225 Duesseldorf, North Rhine-Westphalia ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"2025082619311820400_ref1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0168-8278(86)80073-3","article-title":"Hepatobiliary fibropolycystic diseases. A clinical and histological review of 51 patients","volume":"2","author":"Summerfield","year":"1986","journal-title":"J Hepatol"},{"key":"2025082619311820400_ref2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0025-6196(11)63624-0","article-title":"Ludwig symposium on biliary disorders--part I. 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Prenatal sonographic appearance","volume":"10","author":"Hussman","year":"1991","journal-title":"J Ultrasound Med"},{"key":"2025082619311820400_ref10","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/MEG.0b013e3283470fcd","article-title":"Caroli disease: review of eight cases with emphasis on magnetic resonance imaging features","volume":"23","author":"Lefere","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025082619311820400_ref11","first-page":"477","article-title":"Non-obstructive dilatation of the intrahepatic biliary tree with cholangitis","volume":"41","author":"Murray-Lyon","year":"1972","journal-title":"Q J Med"},{"key":"2025082619311820400_ref12","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.surg.2005.05.002","article-title":"Caroli's disease: liver resection and liver transplantation. Experience in 33 patients","volume":"138","author":"Kassahun","year":"2005","journal-title":"Surgery"},{"key":"2025082619311820400_ref13","first-page":"97","article-title":"Orthotopic liver transplantation for patients with Caroli's disease","volume":"7","author":"Wang","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2025082619311820400_ref14","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/lt.20719","article-title":"Caroli's disease and orthotopic liver transplantation","volume":"12","author":"Habib","year":"2006","journal-title":"Liver Transpl"},{"key":"2025082619311820400_ref15","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.jamcollsurg.2006.02.021","article-title":"The role of surgery in Caroli's disease","volume":"202","author":"Bockhorn","year":"2006","journal-title":"J Am Coll Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/8\/rjaf380\/64141606\/rjaf380.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/8\/rjaf380\/64141606\/rjaf380.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T23:31:24Z","timestamp":1756251084000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf380\/8242030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf380","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,8]]},"article-number":"rjaf380"}}