{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:02Z","timestamp":1753877162696,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gastroesophageal junction pancreatic heterotopia is an uncommon congenital condition where pancreatic tissue is present outside its normal anatomical location. We present a case series of four patients who have presented with nonspecific, vague gastrointestinal symptoms that included abdominal pain, dyspepsia, and heartburn. Endoscopy was performed and revealed irregular Z-lines in three out of the four patients, with high suspicion of Barrett\u2019s esophagus. Further histopathologic evaluation confirmed ectopic pancreatic tissue in all four patients, two of whom had mild chronic inflammation, another presented with chronic gastritis as well as reflux esophagitis, and the last patient exhibited intestinal metaplasia. Also, three patients were treated with proton pump inhibitors and were kept under constant surveillance, while one patient was lost to follow-up. Pancreatic heterotopia involving the gastroesophageal junction is a rare presentation that usually goes unnoticed due to its asymptomatic nature. It is important that clinicians recognize such presentations to provide optimal treatment.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf390","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T12:33:46Z","timestamp":1749472426000},"source":"Crossref","is-referenced-by-count":0,"title":["Gastroesophageal junction pancreatic heterotopia\/metaplasia: a case series"],"prefix":"10.1093","volume":"2025","author":[{"given":"Moaaz","family":"Amir","sequence":"first","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University, College of Medicine , King Faisal Ibn Abd Al Aziz, , 34212, Eastern Province, Dammam ,","place":["Saudi Arabia"]},{"name":"King Faysal University , King Faisal Ibn Abd Al Aziz, , 34212, Eastern Province, Dammam ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Johns Hopkins Aramco Healthcare, Department of Pathology , 8131 Medical Access Rd No. 1, 34465, Eastern Province, Dhahran ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"2025060908334318600_ref1","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0002-9610(86)90045-0","article-title":"Heterotopic pancreas. Review of a 26 year experience","volume":"151","author":"Lai","year":"1986","journal-title":"Am J Surg"},{"key":"2025060908334318600_ref2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.14740\/jmc3838","article-title":"Esophageal pancreatic acinar heterotopia: premalignant or benign","volume":"13","author":"Mills","year":"2022","journal-title":"Journal of medical cases"},{"key":"2025060908334318600_ref3","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1111\/1759-7714.14344","article-title":"Malignant transformation of heterotopic pancreas as middle esophagus adenocarcinoma-a rare case report and comprehensive literature review","volume":"13","author":"Yang","year":"2022","journal-title":"Thoracic cancer"},{"key":"2025060908334318600_ref4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13052-019-0738-3","article-title":"Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature","volume":"45","author":"Persano","year":"2019","journal-title":"Ital J Pediatr"},{"key":"2025060908334318600_ref5","doi-asserted-by":"publisher","first-page":"4695184","DOI":"10.1155\/2020\/4695184","article-title":"A case of heterotopic pancreatic tissue discovered in the distal esophagus","volume":"2020","author":"Shamoon","year":"2020","journal-title":"Case Rep Gastrointest Med"},{"key":"2025060908334318600_ref6","doi-asserted-by":"publisher","first-page":"e1584","DOI":"10.14309\/01.ajg.0000866076.13329.9b","article-title":"S2359 pancreatic heterotopia at gastroesophageal junction","volume":"117","author":"Vikash","journal-title":"Am J Gastroenterol"},{"key":"2025060908334318600_ref7","doi-asserted-by":"publisher","first-page":"e1606","DOI":"10.14309\/01.ajg.0000866248.15872.31","article-title":"A case of heterotropic pancreatic tissue at the gastroesophageal junction","volume":"117","author":"Pabby","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"2025060908334318600_ref8","doi-asserted-by":"publisher","first-page":"e35830","DOI":"10.7759\/cureus.35830","article-title":"Pancreatic heterotopia at the gastroesophageal junction: a case report and review of the literature","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"2025060908334318600_ref9","doi-asserted-by":"publisher","first-page":"e20630","DOI":"10.7759\/cureus.20630","article-title":"Heterotopic pancreas located at the gastroesophageal junction in a hiatal hernia: a case report","volume":"13","author":"Jenkins","year":"2021","journal-title":"Cureus"},{"key":"2025060908334318600_ref10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1148\/rg.2017160091","article-title":"Heterotopic pancreas: histopathologic features, imaging findings, and complications","volume":"37","author":"Rezvani","year":"2017","journal-title":"Radiographics"},{"key":"2025060908334318600_ref11","doi-asserted-by":"publisher","first-page":"464","DOI":"10.5858\/2002-126-0464-GEPH","article-title":"Gastric endocrine pancreatic heterotopia","volume":"126","author":"Lauren","year":"2002","journal-title":"Arch Pathol Lab Med"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf390\/63455777\/rjaf390.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf390\/63455777\/rjaf390.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T12:33:47Z","timestamp":1749472427000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf390\/8158641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf390","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,31]]},"article-number":"rjaf390"}}