{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:32Z","timestamp":1753877252490,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leiomyosarcoma is a rare malignant tumor of smooth muscle, typically found in the uterus and gastrointestinal tract. Its occurrence in the oral cavity is extremely rare due to limited smooth muscle presence. Diagnosis relies on histopathology, and treatment involves wide surgical resection with adjuvant therapy. A 41-year-old male presented with a progressive gingivomandibular swelling for 1 year. He had previously undergone excision of a gingival lesion diagnosed as leiomyoma, which recurred after 1 year. Examination revealed a firm, non-bleeding mass from teeth 37 to 44, with hypoesthesia in the left labiomental region and mobility of the incisivocanine complex. Imaging showed aggressive features, including cortical bone lysis at the symphysis, suggesting malignancy. A biopsy confirmed leiomyosarcoma, and further imaging ruled out metastases or another primary tumor. This case underscores the importance of early diagnosis and aggressive treatment for optimal prognosis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf404","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T11:11:11Z","timestamp":1750072271000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive leiomyosarcoma of the oral cavity: a rare case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9891-7939","authenticated-orcid":false,"given":"Amine","family":"Oussalem","sequence":"first","affiliation":[{"name":"Department of Maxillo-facial Surgery, Specialty Hospital , Area Lamfadel Cherkaoui, Rabat - Institut B.P. 6527, Rabat 10060 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-421X","authenticated-orcid":false,"given":"Bouchra","family":"Dani","sequence":"additional","affiliation":[{"name":"Department of Maxillo-facial Surgery, Specialty Hospital , Area Lamfadel Cherkaoui, Rabat - Institut B.P. 6527, Rabat 10060 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-0597","authenticated-orcid":false,"given":"Malik","family":"Boulaadas","sequence":"additional","affiliation":[{"name":"Department of Maxillo-facial Surgery, Specialty Hospital , Area Lamfadel Cherkaoui, Rabat - Institut B.P. 6527, Rabat 10060 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"2025061607110808500_ref1","first-page":"205","article-title":"Oral leiomyosarcoma: clinical and histopathological features, a review of the literature","volume":"126","author":"Kumar","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2025061607110808500_ref2","first-page":"801","article-title":"Oral leiomyosarcoma: case report and literature review","volume":"14","author":"Patel","year":"2020","journal-title":"Head Neck Pathol"},{"key":"2025061607110808500_ref3","first-page":"223","article-title":"Clinical challenges in diagnosing oral leiomyosarcoma","volume":"12","author":"Kumar","year":"2018","journal-title":"Head Neck Pathol"},{"key":"2025061607110808500_ref4","first-page":"25","article-title":"Immunohistochemical markers in the diagnosis of oral leiomyosarcoma","volume":"94","author":"Ghosh","year":"2019","journal-title":"Oral Oncol"},{"key":"2025061607110808500_ref5","first-page":"50","article-title":"Advances in immunohistochemistry for oral leiomyosarcoma diagnosis","volume":"74","author":"Thompson","year":"2017","journal-title":"Oral Oncol"},{"key":"2025061607110808500_ref6","first-page":"1","article-title":"Metastasis in oral leiomyosarcoma: a review of the literature","volume":"25","author":"Nguyen","year":"2019","journal-title":"Oral Dis"},{"key":"2025061607110808500_ref7","first-page":"453","article-title":"Oral leiomyosarcoma: clinicopathological features and prognosis","volume":"68","author":"Tanaka","year":"2015","journal-title":"J Clin Pathol"},{"key":"2025061607110808500_ref8","first-page":"E2403","article-title":"Surgical resection of oral leiomyosarcoma and its impact on prognosis","volume":"38","author":"Lee","year":"2016","journal-title":"Head Neck"},{"key":"2025061607110808500_ref9","first-page":"213","article-title":"Surgical management of malignant sarcomas of the head and neck","volume":"78","author":"Scher","year":"2020","journal-title":"J Oral Maxillofac Surg"},{"key":"2025061607110808500_ref10","first-page":"514","article-title":"Head and neck soft tissue sarcomas: prognostic factors and therapeutic strategies","volume":"79","author":"Alamillos-Granados","year":"2021","journal-title":"J Oral Maxillofac Surg"},{"key":"2025061607110808500_ref11","first-page":"39","article-title":"Oral leiomyosarcoma presenting as a recurrent hard palate mass: a case report and literature review","volume":"7","author":"Pialago","year":"2020","journal-title":"World Cancer Res J"},{"key":"2025061607110808500_ref12","first-page":"104474","article-title":"Role of radiotherapy in oral leiomyosarcoma treatment","volume":"99","author":"Miller","year":"2019","journal-title":"Oral Oncol"},{"key":"2025061607110808500_ref13","first-page":"105173","article-title":"Outcomes and long-term follow-up in oral leiomyosarcoma","volume":"114","author":"Miller","year":"2021","journal-title":"Oral Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf404\/63498248\/rjaf404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/6\/rjaf404\/63498248\/rjaf404.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T11:11:11Z","timestamp":1750072271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf404\/8163645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf404","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,31]]},"article-number":"rjaf404"}}