{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:14:15Z","timestamp":1756901655384,"version":"3.44.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sclerosing angiomatoid nodular transformation (SANT) of the spleen is an extremely rare benign lesion originating from the splenic red pulp. The pathophysiologic mechanism has not yet been explained thoroughly. These tumors are mostly asymptomatic but cause nonspecific abdominal symptoms. Most SANTs are discovered incidentally on radiographic examination during workup for another disease or during surgery for an unrelated condition. We present a case of a 53-year-old female, whose anemia workup revealed a splenic mass. Progressive enlargement led to the decision of surgical removal. Pathology report of the spleen revealed the rare diagnosis of SANT. After removal, the patient\u2019s anemia gradually improved and on follow-up has completely recovered. Due to the risk of malignancy, surgical removal of the spleen is the preferred management. Careful preoperative planning is important to avoid unexpected hemorrhage during the operation. Depending on the size, open surgery should be preferred over laparoscopic.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf434","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:50:00Z","timestamp":1755085800000},"source":"Crossref","is-referenced-by-count":0,"title":["Sclerosing angiomatoid nodular transformation of the spleen presenting with declining hematocrit: a case report and review of the literature"],"prefix":"10.1093","volume":"2025","author":[{"given":"Konstantinos","family":"Tsigritis","sequence":"first","affiliation":[{"name":"IB Department of Surgery, Henry Dunant Hospital Center , 107 Mesogeion Ave, 11526, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neofytos","family":"Basios","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Pikouli","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysios","family":"Dellaportas","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Papaconstantinou","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios","family":"Kofopoulos-Lymperis","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos M","family":"Charalampous","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Pararas","sequence":"additional","affiliation":[{"name":"3rd Department of Surgery, University Hospital Attikon, National and Kapodistrian University of Athens , 1 Rimini Street, 12462, Athens 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spleen: a case report with FDG-PET findings and literature review","volume":"5","author":"Imamura","year":"2016","journal-title":"Acta Radiol Open"},{"key":"2025081514214479200_ref4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12893-022-01745-2","article-title":"Surgical treatment of benign splenic lesions in pediatric patients: a case series of 30 cases from a single center","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Surg"},{"key":"2025081514214479200_ref5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.amsu.2020.10.048","article-title":"Sclerosing angiomatoid nodular transformation presenting with thrombocytopenia after laparoscopic splenectomy\u2014case report and systematic review of 230 patients","volume":"60","author":"Aziret","year":"2020","journal-title":"Ann Med Surg (Lond)"},{"key":"2025081514214479200_ref6","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.3348\/kjr.2008.9.s.s52","article-title":"CT and MRI findings of sclerosing angiomatoid nodular transformation of the spleen: spoke wheel pattern","volume":"9","author":"Karaosmanoglu","year":"2008","journal-title":"Korean J Radiol"},{"key":"2025081514214479200_ref7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/den.14069","article-title":"Splenic sclerosing angiomatoid nodular transformation diagnosed with endoscopic ultrasound-guided fine needle aspiration","volume":"33","author":"Katsuda","year":"2021","journal-title":"Dig Endosc"},{"key":"2025081514214479200_ref8","doi-asserted-by":"publisher","first-page":"e53907","DOI":"10.7759\/cureus.53907","article-title":"Sclerosing angiomatoid nodular transformation of the spleen in a patient with granulomatosis with polyangiitis","volume":"16","author":"Delgado-de la Mora","year":"2024","journal-title":"Cureus."},{"key":"2025081514214479200_ref9","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.hpb.2020.01.014","article-title":"Treatment options for sclerosing angiomatoid nodular transformation of spleen","volume":"22","author":"Jin","year":"2020","journal-title":"HPB (Oxford)"},{"key":"2025081514214479200_ref10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/21645515.2017.1264797","article-title":"Recommended vaccinations for asplenic and hyposplenic adult patients","volume":"13","author":"Bonanni","year":"2017","journal-title":"Hum Vaccin Immunother"}],"container-title":["Journal of Surgical Case 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