{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:40:33Z","timestamp":1775713233103,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paragangliomas are rare neuroendocrine neoplasms arising from neural crest cells. Among these, primary gallbladder paragangliomas are extremely rare and are typically discovered incidentally during cholecystectomy. This case report describes a 37-year-old female presenting with biliary colic, who underwent laparoscopic cholecystectomy, which revealed a microscopic focus of paraganglioma. Immunohistochemical findings confirmed its benign, parasympathetic nature. Unlike sympathetic paragangliomas, these tumors are non-functioning and effectively managed with surgical resection. This case emphasizes the importance of considering gallbladder paragangliomas in differential diagnoses of biliary lesions and underscores the importance of further research into their pathogenesis, hereditary implications, and optimal management strategies.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf474","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:36:07Z","timestamp":1756467367000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary gallbladder paraganglioma: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Sarah","family":"Mawlaalduwilah","sequence":"first","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences , 11362 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Alammar","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Abdulaziz Medical City in Riyadh , Ibn Alharani St., Villa 4\/b, Riyadh, Riyadh Province 12481 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Alsoghair","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ministry of the National Guard-Health Affairs , 11362 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Al-babtain","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ministry of the National Guard-Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center , 11362 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"2025111209350617000_ref1","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1530\/EJE-14-0396","article-title":"Management of endocrine disease: clinical management of paragangliomas","volume":"171","author":"Corssmit","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"2025111209350617000_ref2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/med\/9780198784272.003.0019","article-title":"Pediatric-onset hypertension and arteriopathies associated with succinate dehydrogenase mutations: case report and literature review","volume":"34","author":"Rees","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"2025111209350617000_ref3","first-page":"536","article-title":"Paragangliomas in head and neck: a case series and review","volume":"231","author":"Roman-Gonzalez","year":"2020","journal-title":"J Am Coll Surg"},{"key":"2025111209350617000_ref4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.5858\/2005-129-523-GPACRW","article-title":"Gallbladder paraganglioma: a case report with molecular analysis and review of the literature","volume":"129","author":"Rosales","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"2025111209350617000_ref5","first-page":"1103","article-title":"Paraganglioma of the orbit: a rare case report and literature review","volume":"56","author":"Zaccarello","year":"2021","journal-title":"J Pediatr Surg"},{"key":"2025111209350617000_ref6","first-page":"287","volume-title":"Comparative Endocrinology","author":"Widmann","year":"2015","edition":"3rd"},{"key":"2025111209350617000_ref7","volume-title":"Pheochromocytoma and Paraganglioma Treatment (PDQ\u00ae)\u2014Patient Version","author":"National Cancer Institute","year":"2019"},{"key":"2025111209350617000_ref8","first-page":"161","article-title":"Strategies for reoperation in patients with recurrent paragangliomas: case series and review","volume":"122","author":"Heerdt","year":"1987","journal-title":"JAMA Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf474\/65276049\/rjaf474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf474\/65276049\/rjaf474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:35:15Z","timestamp":1762958115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf474\/8321776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf474","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11,1]]},"article-number":"rjaf474"}}