{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:23:29Z","timestamp":1789057409580,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ewing Sarcoma (ES) is a rare, aggressive malignancy typically seen in younger people, with diagnosis in older adults being uncommon. We present a case of a 70-year-old woman with ES. She presented with a common complaint of referred lower extremity pain that started without injury. However, unusual clinical features included generalized pruritus and nocturnal pain. Thus, it was decided to proceed with imaging. MRI revealed an intradural L3\u2013L4 mass, initially suspected to be a schwannoma, considering homogenous contrast enhancement and no sign of invasion of the surrounding tissues. Her condition was not improving and was unresponsive to oral steroids. Surgical intervention yielded a pathology report confirming ES. She underwent radiation and chemotherapy but experienced complications, including thrombocytopenia and neutropenia. ES in older adults is rare, often presenting atypically and carrying a guarded prognosis. This case underscores the need for age-specific protocols and improved management strategies.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf489","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T23:32:40Z","timestamp":1752276760000},"source":"Crossref","is-referenced-by-count":1,"title":["Challenges in diagnosing and managing Ewing sarcoma in older adults: a case report of Ewing sarcoma presenting as seemingly uncomplicated back pain"],"prefix":"10.1093","volume":"2025","author":[{"given":"Haley N","family":"Bayne","sequence":"first","affiliation":[{"name":"Department of Medicine, Robert Larner College of Medicine at the University of Vermont , 89 Beaumont Ave, Burlington, VT 05405 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Ellsworth","sequence":"additional","affiliation":[{"name":"Department of Pathology at Columbia University Medical Center , 622 W 168th St, New York, NY 10032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma","family":"Karlovich","sequence":"additional","affiliation":[{"name":"Department of Pathology at Columbia University Medical Center , 622 W 168th St, New York, NY 10032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Al Dalahmah","sequence":"additional","affiliation":[{"name":"Department of Pathology at Columbia University Medical Center , 622 W 168th St, New York, NY 10032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Tikhomirov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine at Danbury Hospital , 24 Hospital Ave, Danbury, CT 06810 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"2025071119323572800_ref1","first-page":"312","article-title":"Ewing sarcoma in adults: epidemiology, diagnosis, and management","volume":"41","author":"Zollner","year":"2018","journal-title":"Am J Clin Oncol"},{"key":"2025071119323572800_ref2","volume-title":"StatPearls [Internet]","author":"Durer","year":"2025"},{"key":"2025071119323572800_ref3","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1073\/pnas.0610998104","article-title":"Haplotype structure and selection of the MDM2 oncogene in humans","volume":"104","author":"Atwal","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"2025071119323572800_ref4","doi-asserted-by":"publisher","first-page":"4929","DOI":"10.1007\/s11033-013-2593-4","article-title":"Ewing sarcoma: influence of tp53 arg72pro and Mdm2 T309g 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