{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:16:55Z","timestamp":1780697815366,"version":"3.54.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Critical size segmental bone defects represent a challenging problem. Recently, personalized, structured three-dimensional graft cages have been developed to improve ingrowth of autologous bone material and reduce resorption. A 44-year-old patient presented with an open tibial shaft fracture after a motorcycle incident with minor bone loss. Following intramedullary nailing, an acute infection developed that required removal of ~4\u00a0cm bone in a circular mode. After multiple interventions, a personalized 3D-printed graft cage was implanted and filled with autologous bone material, harvested by intramedullary reaming from the ipsilateral femur. Ten months postoperatively, the patient is completely pain free and shows good clinical and radiological status. In conclusion, use of a 3D-printed graft cage in combination with Reamer Irrigator Aspirator (RIA) might represent a new additional feature for larger bone defects to avoid gravity or perfusion related resorption of large area defects.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf493","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:55:54Z","timestamp":1750319754000},"source":"Crossref","is-referenced-by-count":2,"title":["Use of personalized graft cage and RIA bone graft in a case of acute infection following a grade 2 open tibial shaft fracture: a new option for bone grafting in patients with critical size segmental bone defects"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9285-8660","authenticated-orcid":false,"given":"Christian Thomas","family":"H\u00fcbner","sequence":"first","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Veenstra","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Karl-Ludwig","family":"Klingebiel","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bayer","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Landre","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro-Michael","family":"Heining","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hierholzer","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Trauma, University Hospital Zurich, University of Zurich , Raemistrasse 100, 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"2025071602182180900_ref1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00441-011-1184-8","article-title":"Treatment of long bone defects and non-unions: from research to clinical practice","volume":"347","author":"Berner","year":"2012","journal-title":"Cell Tissue Res"},{"key":"2025071602182180900_ref2","doi-asserted-by":"publisher","first-page":"6283","DOI":"10.3390\/jcm12196283","article-title":"Current management of diaphyseal long bone defects\u2014a multidisciplinary and international perspective","volume":"12","author":"Rosslenbroich","year":"2023","journal-title":"J Clin Med"},{"key":"2025071602182180900_ref3","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.2106\/JBJS.18.00842","article-title":"Bone repair using the Masquelet technique","volume":"101","author":"Masquelet","year":"2019","journal-title":"JBJS"},{"key":"2025071602182180900_ref4","first-page":"287","article-title":"The reamer-irrigator-aspirator system: a review","volume":"29","author":"Billow","year":"2016","journal-title":"Surg Technol Int"},{"key":"2025071602182180900_ref5","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.2106\/JBJS.19.00804","article-title":"Bone-graft resorption reduced by the induced membrane technique and factors affecting volumetric changes: an analysis of 120 serial computed tomographic scans in 40 patients","volume":"102","author":"Cho","year":"2020","journal-title":"J Bone Joint Surg Am"},{"key":"2025071602182180900_ref6","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1097\/BOT.0b013e318274da8b","article-title":"Physiological challenges of bone repair","volume":"26","author":"Borrelli","year":"2012","journal-title":"J Orthop Trauma"},{"key":"2025071602182180900_ref7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3390\/jfb14070341","article-title":"The concept of scaffold-guided bone regeneration for the treatment of long bone defects: current clinical application and future perspective","volume":"14","author":"Laubach","year":"2023","journal-title":"J Funct Biomater"},{"key":"2025071602182180900_ref8"},{"key":"2025071602182180900_ref9","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.4081\/or.2016.6384","article-title":"Bone transport for limb reconstruction following severe tibial fractures","volume":"8","author":"F\u00fcrmetz","year":"2016","journal-title":"Orthop Rev (Pavia)"},{"key":"2025071602182180900_ref10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5005\/jp-journals-10080-1562","article-title":"Pin-site infection: a systematic review of prevention strategies","volume":"17","author":"Shields","year":"2022","journal-title":"Strategies Trauma Limb Reconstr"},{"key":"2025071602182180900_ref11","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1097\/BOT.0000000000002574","article-title":"Management of segmental tibial bone defects with the magnetic motorized intramedullary transport nail: a case series","volume":"37","author":"Geiger","year":"2023","journal-title":"J Orthop Trauma"},{"key":"2025071602182180900_ref12","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S0001-2092(06)62978-5","article-title":"Calcium phosphate bone cement--the Norian skeletal repair system in orthopedic surgery","volume":"65","author":"Cohen","year":"1997","journal-title":"AORN J"},{"key":"2025071602182180900_ref13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0736-0266(03)00165-7","article-title":"Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration","volume":"22","author":"Pelissier","year":"2004","journal-title":"J Orthop Res"},{"key":"2025071602182180900_ref14","article-title":"Biological implementation of \u2018in situ\u2019 induced autologous foreign body membranes in consolidation of massive cancellous bone grafts","volume":"79","author":"Klaue","year":"1993","journal-title":"J Bone Joint Surg"},{"key":"2025071602182180900_ref15","article-title":"First clinical use of TRUMATCH\u2122 graft cage \u2013 long bone","author":"Jordan","journal-title":"De Puy Synthes"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf493\/63773140\/rjaf493.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf493\/63773140\/rjaf493.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T06:18:29Z","timestamp":1752646709000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf493\/8203124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf493","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7]]},"article-number":"rjaf493"}}