{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:41:27Z","timestamp":1793832087723,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perianal Paget\u2019s disease is an uncommon and difficult to treat disease due to the high risk of positive margin at resection and high risk for recurrence. It can arise as a primary tumor or secondary to underlying pelvic visceral malignancy and is often initially misdiagnosed as an inflammatory perianal rash until proper pathologic diagnosis has been confirmed. We present the case of a 76-year-old woman who presented with 2 years of a perianal rash unsuccessfully treated with various topical interventions. Eventually, a biopsy was performed revealing extramammary Paget\u2019s disease and she underwent surgical excision of the perianal lesion. Operative pathology unfortunately exhibited positive margins and we detail the multidisciplinary discussion of further management options in this complicated clinical dilemma. This case highlights the importance of early recognition of this disease and a multidisciplinary approach to its treatment.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf528","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:45:26Z","timestamp":1752486326000},"source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic delays and nuanced surgical management in perianal Paget\u2019s disease: a case report and review of current literature"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-7084","authenticated-orcid":false,"given":"Cyprien","family":"Jungels","sequence":"first","affiliation":[{"name":"HCA HealthOne, Swedish General Surgery Residency, Swedish Medical Center , 501 E Hampden Ave, Englewood, CO 80113,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Bedard","sequence":"additional","affiliation":[{"name":"HCA HealthOne, Swedish General Surgery Residency, Swedish Medical Center , 501 E Hampden Ave, Englewood, CO 80113,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daine","family":"Bennett","sequence":"additional","affiliation":[{"name":"SurgOne, PC , Colorectal Surgery, 8490 E Crescent Parkway, Suite 380, Greenwood Village, CO 80111,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"2025071405452438600_ref1","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1111\/codi.16549","article-title":"Perianal Paget\u2019s\u2014an aggressive disease","volume":"25","author":"Rudnicki","year":"2023","journal-title":"Colorectal Dis"},{"key":"2025071405452438600_ref2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/DCR.0000000000000100","article-title":"Management and outcome of perianal Paget's disease: a 6-decade institutional 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Surg"},{"key":"2025071405452438600_ref9","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1159\/000256382","article-title":"Extramammary perianal Paget's disease","volume":"3","author":"Al Hallak","year":"2009","journal-title":"Case Rep Gastroenterol"},{"key":"2025071405452438600_ref10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1046\/j.1365-2133.2000.03242.x","article-title":"The Roswell Park Cancer Institute experience with extramammary Paget's disease","volume":"142","author":"Zollo","year":"2000","journal-title":"Br J Dermatol"},{"key":"2025071405452438600_ref11","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/BF02055165","article-title":"Paget's disease of the perianal region\u2014an aggressive disease","volume":"40","author":"Sarmiento","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"2025071405452438600_ref12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1006\/gyno.1995.1044","article-title":"Extramammary Paget's 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Meeting abstracts from the 2024 annual scientific meeting of the American Society of Colon and Rectal Surgeons","volume":"67","author":"Jungels","year":"2024","journal-title":"Dis Colon Rectum"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf528\/63742576\/rjaf528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf528\/63742576\/rjaf528.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:45:27Z","timestamp":1752486327000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf528\/8198754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf528","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7]]},"article-number":"rjaf528"}}