{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:26:49Z","timestamp":1780514809687,"version":"3.54.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Combined treatment with atezolizumab (ATZ) and bevacizumab (BV) is the first-line therapy for unresectable advanced hepatocellular carcinoma (HCC). We report a rare case of hepatocolic fistula during ATZ\u2009+\u2009BV therapy, successfully treated with salvage hepatectomy. A 72-year-old man with advanced HCC underwent treatment with ATZ\u2009+\u2009BV. After seven cycles, he presented with abdominal pain. Imaging revealed ascites and free air, leading to an emergency laparotomy, where panperitonitis was diagnosed. Despite lavage and drainage, postoperative fever persisted. Further imaging identified a liver abscess, requiring emergency ultrasound-guided percutaneous drainage. Contrast studies confirmed a hepatocolic fistula. The patient underwent ileostomy for abscess management, followed by extended posterior sectionectomy and right hemicolectomy on Day 25. He was discharged 37\u00a0days after final surgery without complications.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf532","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:32:37Z","timestamp":1752723157000},"source":"Crossref","is-referenced-by-count":1,"title":["Hepatocolic fistula in hepatocellular carcinoma treated with atezolizumab\u2013bevacizumab: a case report on successful salvage hepatectomy"],"prefix":"10.1093","volume":"2025","author":[{"given":"Kota","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Ushida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2615-8941","authenticated-orcid":false,"given":"Takayuki","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ei","family":"Sekoguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kurumiya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyota Kosei Hospital , 500-1 Josui-cho, Toyota, Aichi 470-0396 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"2025071623323095000_ref1","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"2025071623323095000_ref2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/hepr.13734","article-title":"Early experience of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma BCLC-B stage patients classified as beyond up to seven criteria\u2014multicenter analysis","volume":"52","author":"Hiraoka","year":"2022","journal-title":"Hepatol Res"},{"key":"2025071623323095000_ref3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3904\/kjim.2007.22.2.106","article-title":"Journey of a swallowed toothbrush to the colon","volume":"22","author":"Kim","year":"2007","journal-title":"Korean J Intern Med"},{"key":"2025071623323095000_ref4","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1007\/s10620-006-9198-x","article-title":"Hepatic abscess that formed secondary to fish bone and had a fistula with the ascending colon","volume":"52","author":"Kim","year":"2007","journal-title":"Dig Dis Sci"},{"key":"2025071623323095000_ref5","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4166\/kjg.2011.58.5.270","article-title":"Abscesso-colonic fistula following radiofrequency ablation therapy for hepatocellular carcinoma; a case successfully treated with histoacryl embolization","volume":"58","author":"Kim","year":"2011","journal-title":"Korean J Gastroenterol"},{"key":"2025071623323095000_ref6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.4174\/jkss.2013.84.4.256","article-title":"Right side fixation of sigmoid colon with a hepato-sigmoidocolic fistula in patient with hepatocellular carcinoma and midgut malrotation","volume":"84","author":"Choi","year":"2013","journal-title":"J Korean Surg Soc"},{"key":"2025071623323095000_ref7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1308\/003588413X13629960048550","article-title":"Hepatocolonic fistula: a rare consequence of retained gallstones after laparoscopic cholecystectomy","volume":"95","author":"Stevens","year":"2013","journal-title":"Ann R Coll Surg Engl"},{"key":"2025071623323095000_ref8","first-page":"27","article-title":"Nature heals: spontaneous resolution of liver abscess through hepatocolic fistula","volume":"1","author":"Ishwar","year":"2015","journal-title":"IJSS Case Rep Rev"},{"key":"2025071623323095000_ref9","doi-asserted-by":"publisher","first-page":"bcr2016219141","DOI":"10.1136\/bcr-2016-219141","article-title":"Hepatocolic fistula: a rare presentation of pyogenic liver abscess","volume":"2017","author":"Timbol","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2025071623323095000_ref10","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S1470-2045(09)70142-1","article-title":"Bevacizumab-associated gastrointestinal perforation","volume":"10","author":"Chau","year":"2009","journal-title":"Lancet Oncol"},{"key":"2025071623323095000_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1721","article-title":"A case of HCC successfully treated with infliximab-steroid sequential therapy for small bowel perforation due to atezolizumab\/bevacizumab combination therapy","volume":"5","author":"Hagiwara","year":"2022","journal-title":"Cancer Rep (Hoboken)"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf532\/63779967\/rjaf532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf532\/63779967\/rjaf532.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:32:37Z","timestamp":1752723157000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf532\/8203575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf532","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7]]},"article-number":"rjaf532"}}