{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:29:42Z","timestamp":1781580582902,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chondroid syringoma is a rare benign cutaneous adnexal tumor, most commonly found in the head and neck region. Its occurrence on the upper lip is exceptional. We report a case involving a 63-year-old man presenting with a painless, firm swelling of the left upper lip that gradually enlarged over three years. Clinical examination revealed a 1.6\u00a0cm submucosal nodule. Surgical excision with a 3\u00a0mm margin and direct closure using 5\u20130 Vicryl Rapide sutures was performed. Histopathological and immunohistochemical analysis confirmed the diagnosis of chondroid syringoma. No recurrence or functional\/aesthetic complications were observed during 12\u00a0months of follow-up. This report underscores the diagnostic difficulties posed by this rare location, discusses differential diagnoses with other adnexal and salivary gland tumors, and reviews management considerations based on current literature.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf541","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:45:35Z","timestamp":1752720335000},"source":"Crossref","is-referenced-by-count":2,"title":["Chondroid syringoma of the upper lip: a rare case highlighting diagnostic challenges and literature review"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9891-7939","authenticated-orcid":false,"given":"Amine","family":"Oussalem","sequence":"first","affiliation":[{"name":"Specialty Hospital, Department of Maxillo-Facial Surgery, Area Lamfadel Cherkaoui, Rabat - Institut B.P 6527, Rabat ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-421X","authenticated-orcid":false,"given":"Bouchra","family":"Dani","sequence":"additional","affiliation":[{"name":"Specialty Hospital, Department of Maxillo-Facial Surgery, Area Lamfadel Cherkaoui, Rabat - Institut B.P 6527, Rabat ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-0597","authenticated-orcid":false,"given":"Malik","family":"Boulaadas","sequence":"additional","affiliation":[{"name":"Specialty Hospital, Department of Maxillo-Facial Surgery, Area Lamfadel Cherkaoui, Rabat - Institut B.P 6527, Rabat ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"2025071622453080100_ref1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00256-003-0633-1","article-title":"Chondroid syringoma: imaging features and histopathologic correlation","volume":"32","author":"Nguyen","year":"2003","journal-title":"Skeletal Radiol"},{"key":"2025071622453080100_ref2","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1111\/ijd.14987","article-title":"Chondroid syringoma of the upper lip: a rare location","volume":"59","author":"Goyal","year":"2020","journal-title":"Int J Dermatol"},{"key":"2025071622453080100_ref3","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1097\/DSS.0000000000003077","article-title":"Suture selection in facial surgery: a review of outcomes","volume":"47","author":"Kappel","year":"2021","journal-title":"Dermatol Surg"},{"key":"2025071622453080100_ref4","volume-title":"Skin Pathology","author":"Weedon","year":"2010","edition":"4th"},{"key":"2025071622453080100_ref5","first-page":"456","article-title":"Chondroid syringoma of the upper lip: diagnostic pitfalls","volume":"44","author":"Lee","year":"2017","journal-title":"J Cutan Pathol"},{"key":"2025071622453080100_ref6","first-page":"288","article-title":"Recurrent chondroid syringoma of the lip","volume":"41","author":"Rossi","year":"2015","journal-title":"Dermatol Surg"},{"key":"2025071622453080100_ref7","first-page":"S250","article-title":"Lip adnexal tumors: a 20-year review","volume":"86","author":"Kumar","year":"2021","journal-title":"Ann Plast Surg"},{"key":"2025071622453080100_ref8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.0303-6987.2004.00196.x","article-title":"Chondroid syringoma of skin: a clinicopathological and immunohistochemical study of 12 cases","volume":"31","author":"Kazakov","year":"2004","journal-title":"J Cutan Pathol"},{"key":"2025071622453080100_ref9","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/jso.23758","article-title":"Surgical excision margins for benign skin adnexal tumors","volume":"110","author":"Khare","year":"2015","journal-title":"J Surg Oncol"},{"key":"2025071622453080100_ref10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1046\/j.1524-4725.1999.08158.x","article-title":"Malignant chondroid syringoma: a case report and review of the literature","volume":"25","author":"Turegun","year":"1999","journal-title":"Dermatol Surg"},{"key":"2025071622453080100_ref11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13000-015-0411-0","article-title":"Malignant chondroid syringoma: clinicopathologic study of four cases and literature review","volume":"10","author":"Qian","year":"2015","journal-title":"Diagn Pathol"},{"key":"2025071622453080100_ref12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.det.2018.03.002","article-title":"Cutaneous adnexal tumors: a review of selected neoplasms","volume":"36","author":"Carli","year":"2018","journal-title":"Dermatol Clin"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf541\/63779842\/rjaf541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/7\/rjaf541\/63779842\/rjaf541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:45:37Z","timestamp":1752720337000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf541\/8203565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf541","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7]]},"article-number":"rjaf541"}}