{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:32:25Z","timestamp":1754159545777,"version":"3.41.2"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ehlers-Danlos Syndromes (EDS) are a group of genetic connective tissue disorders classified into to 13 subtypes according to different genetic mutations. The vascular subtype, also known as Type IV, is considered the most severe subtype and is associated with dire complications. Spontaneous gastrointestinal perforation is the most commonly described digestive complication, with colonic perforation accounting for most cases. We report a challenging case of EDS, diagnosed with colonic perforation as the initial presentation of the disease.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf558","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T14:21:56Z","timestamp":1753453316000},"source":"Crossref","is-referenced-by-count":0,"title":["Ehlers-Danlos syndrome and the risk of spontaneous colonic perforation: clinical insights and surgical implications"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-4653","authenticated-orcid":false,"given":"Daniela","family":"Gaspar","sequence":"first","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-8512","authenticated-orcid":false,"given":"Jo\u00e3o L","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Faculty of Health Sciences, University of Beira Interior , Convento de Santo Ant\u00f3nio, 6201-001, Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-8882","authenticated-orcid":false,"given":"Andreia","family":"Santos","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Canhoto","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-6480","authenticated-orcid":false,"given":"Raquel Barros","family":"Pereira","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Pereira","sequence":"additional","affiliation":[{"name":"General Surgery Department, Unidade Local de Sa\u00fade \u2013 Viseu D\u00e3o Laf\u00f5es , Av. Rei Dom Duarte, 3504-009 Viseu ,","place":["Portugal"]},{"name":"Clinical Academic Center of Beiras (CACB) , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]},{"name":"Edif\u00edcio UBImedical , , Estrada Municipal 506, 6200-284 Covilh\u00e3 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"2025072510215313300_ref1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.23922\/jarc.2020-029","article-title":"Surgical management of colonic perforation in a patient with vascular Ehlers-Danlos syndrome with no family history: a case report","volume":"4","author":"Kanaka","year":"2020","journal-title":"J Anus Rectum Colon"},{"key":"2025072510215313300_ref2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10151-018-1783-4","article-title":"Bowel perforation in type IV vascular Ehlers\u2013Danlos syndrome. 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