{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:27:20Z","timestamp":1757622440901,"version":"3.44.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Metastatic Crohn\u2019s disease (MCD) is a rare extraintestinal manifestation of Crohn\u2019s disease (CD), particularly in pediatric patients. It refers to cutaneous involvement at areas distant and non-contiguous from the bowel. We present a boy with a 1.5-year history of perianal lesions, penoscrotal swelling, and intermittent hematochezia. Examination revealed hepatosplenomegaly, perianal erythematous plaques, and inguinoscrotal swelling. Biopsy of the scrotal skin revealed non-caseating granulomatous inflammation, suggestive of MCD. Stool calprotectin was elevated, however, gastrointestinal biopsies were suggestive of indeterminate colitis. Initial management with symptomatic treatment provided limited relief, and he was later started on oral immunomodulators. This case highlights MCD as a rare but significant initial presentation of CD in pediatric patients and emphasizes the need for increased awareness of MCD in children with unexplained cutaneous lesions.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf704","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T19:47:11Z","timestamp":1757360831000},"source":"Crossref","is-referenced-by-count":0,"title":["Penoscrotal swelling as a presentation of Crohn\u2019s disease"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7249-7955","authenticated-orcid":false,"given":"Dhruv","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children , Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivangi","family":"Tetarbe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children , Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology, Bai Jerbai Wadia Hospital for Children , Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children , Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"2025090815470698200_ref1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4103\/1658-631X.178356","article-title":"Scrotal abscess, an unusual manifestation of Crohn's disease","volume":"4","author":"Aldamanhori","year":"2016","journal-title":"Saudi J Med Med Sci"},{"key":"2025090815470698200_ref2","doi-asserted-by":"publisher","first-page":"E379","DOI":"10.5489\/cuaj.4326","article-title":"Case: metastatic Crohn's disease of the genitalia in a prepubescent male: an illustrative case of an uncommon diagnosis","volume":"11","author":"Kim","year":"2017","journal-title":"Can Urol Assoc J"},{"volume-title":"In: StatPearls","year":"2025","author":"Bernett","key":"2025090815470698200_ref3"},{"key":"2025090815470698200_ref4","first-page":"E33","article-title":"Metastatic Crohn disease: a review of dermatologic manifestations and treatment","volume":"99","author":"Bender-Heine","year":"2017","journal-title":"Cutis"},{"key":"2025090815470698200_ref5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/ddg.12861","article-title":"Metastatic Crohn's disease in childhood","volume":"14","author":"Sabbadini","year":"2016","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf704\/64223569\/rjaf704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf704\/64223569\/rjaf704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T19:47:12Z","timestamp":1757360832000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf704\/8249383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf704","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"rjaf704"}}