{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:50:23Z","timestamp":1758361823771,"version":"3.44.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Enteropathogenic Escherichia coli (EPEC) is a pathogenic strain of E. coli. Mesenteric vein thrombophlebitis is of surgical concern, as there is a risk of the development of bowel ischemia. We present a unique case of a patient with EPEC diarrhea who subsequently developed ileocolic thrombophlebitis. Our patient presented to the emergency department with 6\u00a0days of diarrhea and abdominal pain. A computed tomography angiography (CTA) abdomen and pelvis was performed which revealed occlusion of the ileocolic vein with perivenous inflammation, consistent with mesenteric thrombophlebitis. A gastrointestinal polymerase chain reaction (GI PCR) was positive for EPEC. The patient was managed non-operatively with intravenous antibiotics and anticoagulation with resolution of symptoms. Ileocolic thrombophlebitis is a rare cause of acute abdominal pain. Our patient is one of the first documented cases to develop thrombophlebitis following EPEC infection. We hypothesize the EPEC infection and inflammation predisposed our patient to developing ileocolic thrombophlebitis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf740","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:27:02Z","timestamp":1757417222000},"source":"Crossref","is-referenced-by-count":0,"title":["Ileocolic venous thrombophlebitis from associated enteropathogenic <i>E. coli<\/i> infection"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-1627","authenticated-orcid":false,"given":"Brendan P","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of General Surgery, UConn Health Center , 263 Farmington Ave, Farmington, CT 06032 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Yuan C","family":"Kao","sequence":"additional","affiliation":[{"name":"UConn School of Medicine , 263 Farmington Ave, Farmington, CT 06032 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-0543","authenticated-orcid":false,"given":"Kristina","family":"Kuklova","sequence":"additional","affiliation":[{"name":"Department of General Surgery, UConn Health Center , 263 Farmington Ave, Farmington, CT 06032 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Alaoudi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Hospital of Central Connecticut, Hartford Healthcare , 100 Grand St, New Britain, CT 06106 \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"2025091915292242200_ref1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/J.JINF.2007.07.016","article-title":"Advances in defining etiology and new therapeutic approaches in acute diarrhea","volume":"55","author":"Marcos","year":"2007","journal-title":"J Infect"},{"key":"2025091915292242200_ref2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/J.BJM.2016.10.015","article-title":"Diarrheagenic Escherichia coli","volume":"47","author":"Gomes","year":"2016","journal-title":"Braz J Microbiol"},{"key":"2025091915292242200_ref3","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/QCO.0B013E32834A8B8B","article-title":"Enteropathogenic escherichia coli infection in children","volume":"24","author":"Ochoa","year":"2011","journal-title":"Curr Opin Infect Dis"},{"key":"2025091915292242200_ref4","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/J.DLD.2007.04.015","article-title":"Pylephlebitis and mesenteric thrombophlebitis in sigmoid diverticulitis: medical approach, delayed surgery","volume":"39","author":"Nobili","year":"2007","journal-title":"Dig Liver Dis"},{"key":"2025091915292242200_ref5","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.3748\/WJG.14.4580","article-title":"Septic thrombophlebitis of the Porto-mesenteric veins as a complication of acute appendicitis","volume":"14","author":"Chang","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2025091915292242200_ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5341281","article-title":"Pylephlebitis: a case of inferior mesenteric vein thrombophlebitis in a patient with acute sigmoid diverticulitis-a case report and clinical management review","volume":"2019","author":"Zia","year":"2019","journal-title":"Case Rep Infect Dis"},{"key":"2025091915292242200_ref7","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/J.RADCR.2023.02.014","article-title":"Inferior mesenteric vein thrombophlebitis secondary to acute diverticulitis","volume":"18","author":"Waack","year":"2023","journal-title":"Radiol Case Rep"},{"key":"2025091915292242200_ref8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/J.IJSCR.2011.10.019","article-title":"Isolated superior mesenteric venous thrombophlebitis with acute appendicitis","volume":"4","author":"Karam","year":"2013","journal-title":"Int J Surg Case Rep"},{"key":"2025091915292242200_ref9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1007\/S11239-019-01816-X","article-title":"Clinical implications of different risk factor profiles in patients with mesenteric venous thrombosis and systemic venous thromboembolism: a population-based study","volume":"47","author":"Salim","year":"2019","journal-title":"J Thromb Thrombolysis"},{"key":"2025091915292242200_ref10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/J.JCEH.2014.03.052","article-title":"Mesenteric venous thrombosis","volume":"4","author":"Hmoud","year":"2014","journal-title":"J Clin Exp Hepatol"},{"key":"2025091915292242200_ref11","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.29019","article-title":"Ileocolic thrombophlebitis and lymphadenitis mimicking acute appendicitis as a late manifestation in a COVID-19 patient: a case report","volume":"14","author":"Chou","year":"2022","journal-title":"Cureus"},{"key":"2025091915292242200_ref12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/S12098-015-1817-0","article-title":"Acute appendicitis complicated with ileocolic vein thrombosis","volume":"83","author":"Sato","year":"2016","journal-title":"Indian J Pediatr"},{"key":"2025091915292242200_ref13","doi-asserted-by":"publisher","first-page":"S1925","DOI":"10.14309\/01.AJG.0001040484.17184.83\u20136","article-title":"S2779 a rare case of cecal and ascending colon diverticulitis with ileocolic vein thrombophlebitis","volume":"119","author":"Teja Nuthalapati","year":"2024","journal-title":"American Journal of Gastroenterology"},{"key":"2025091915292242200_ref14","doi-asserted-by":"publisher","DOI":"10.14744\/ejmo.2017.36844","article-title":"A rare cause of acute abdomen: thrombosis in the ileocolic branch of the superior mesenteric vein","volume-title":"EJMO","author":"Sirkeci O, Erkus Sirkeci E, Ergun H.","year":"2018"},{"key":"2025091915292242200_ref15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/J.JCEH.2014.03.052","article-title":"Mesenteric venous thrombosis","volume":"4","author":"Hmoud","year":"2014","journal-title":"J Clin Exp Hepatol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf740\/64263665\/rjaf740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf740\/64263665\/rjaf740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T19:29:30Z","timestamp":1758310170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf740\/8253768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf740","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"rjaf740"}}