{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:33:52Z","timestamp":1780457632837,"version":"3.54.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present a rare case of primary undifferentiated pleomorphic sarcoma (UPS) of the chest wall in a 45-year-old male, initially diagnosed as sarcomatoid pleural mesothelioma via computed tomography (CT)-guided biopsy. CT revealed a large tumor measuring 13\u2009\u00d7\u200912\u00a0cm occupying the left thoracic cavity, with extensive invasion into the left first through fifth ribs and the adjacent lung parenchyma. The patient was referred to our hospital and treated with a combination of nivolumab and ipilimumab, resulting in marked tumor regression. Upon reevaluation, the diagnosis was revised to sarcoma, and the patient subsequently underwent salvage surgery, including resection of the left upper lung lobe and first through fifth ribs. Histopathology confirmed tumor mutational burden-high UPS. The patient has remained disease-free for two and a half years postoperatively. This case demonstrates the potential efficacy of immune checkpoint inhibitors in multimodal treatment for select cases of chest wall UPS.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf747","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:23:55Z","timestamp":1756725835000},"source":"Crossref","is-referenced-by-count":1,"title":["Salvage resection after immunotherapy for giant undifferentiated pleomorphic sarcoma of the chest wall"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-9527","authenticated-orcid":false,"given":"Akifumi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Hematology, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kijima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Hematology, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0386-1952","authenticated-orcid":false,"given":"Seiki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Takarazuka City Hospital , 4-5-1, Kohama, Takarazuka, Hyogo 665-0827,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Funaki","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University , 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"2025102700064610800_ref1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.21037\/cco-23-71","article-title":"A systematic review of undifferentiated pleomorphic sarcoma of the chest wall","volume":"12","author":"Bennett","year":"2023","journal-title":"Chin Clin Oncol"},{"key":"2025102700064610800_ref2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s11547-018-0882-7","article-title":"The pathology of soft tissue sarcomas","volume":"124","author":"Sbaraglia","year":"2019","journal-title":"Radiol 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and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial","volume":"18","author":"Tawbi","year":"2017","journal-title":"Lancet Oncol"},{"key":"2025102700064610800_ref6","doi-asserted-by":"crossref","first-page":"LBA11501","DOI":"10.1200\/JCO.2022.40.17_suppl.LBA11501","article-title":"Randomized phase II study of neoadjuvant checkpoint blockade for surgically resectable undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated liposarcoma (DDLPS): survival results after 2 years of follow-up and intratumoral B-cell receptor (BCR) correlates","volume":"40","author":"Keung","year":"2022","journal-title":"J Clin Oncol"}],"container-title":["Journal of Surgical Case 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