{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:21:47Z","timestamp":1770891707883,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Splenic metastasis is uncommon, and truly isolated splenic metastasis (ISM) from breast cancer is a clinical rarity. Contemporary autopsy series reports splenic involvement in &amp;lt;1% of breast cancer-related deaths, and fewer than 15 well-documented ISM cases have been published. We report a 71-year-old woman presenting with a right-breast mass, regional lymphadenopathy, and a solitary splenic lesion detected on staging computed tomography (CT) and positron emission tomography-CT. Biopsy confirmed hormone receptor-negative, HER2-positive invasive ductal carcinoma. Six cycles of docetaxel, trastuzumab, and pertuzumab led to a 59% reduction in the primary tumour and complete radiological resolution of the splenic lesion. The patient remains progression-free 22\u00a0months after initiating therapy, maintained on trastuzumab and pertuzumab. Although extremely rare, ISM can present as the initial manifestation of de novo metastatic breast cancer. Awareness of this possibility may facilitate early systemic therapy and obviate the need for diagnostic splenectomy.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf751","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:47:52Z","timestamp":1756813672000},"source":"Crossref","is-referenced-by-count":1,"title":["Isolated splenic metastasis presenting at diagnosis of HER2-positive <i>de novo<\/i> metastatic breast cancer: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Maika","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Department of Breast Surgery, Sakai City Medical Center , 1-1-1 Ebaraji-cho, Nishi-ku, Sakai, Osaka 593-8304 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanae","family":"Masunaga","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Tsukabe","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiro","family":"Yoshinami","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Sota","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Tanei","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Graduate School of Medicine, University of Osaka , 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"2025092008215235200_ref1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.prp.2005.12.008","article-title":"Splenic metastases in a large unselected autopsy series","volume":"202","author":"Sch\u00f6n","year":"2006","journal-title":"Pathol Res Pract"},{"key":"2025092008215235200_ref2","first-page":"442","article-title":"Secondary carcinoma of the spleen. Its incidence in 544 cases and a review of the literature","volume":"58","author":"Nash","year":"1966","journal-title":"J Natl Med Assoc"},{"key":"2025092008215235200_ref3","first-page":"281","article-title":"The incidence of splenic metastasis of carcinoma","volume":"76","author":"Herbert","year":"1952","journal-title":"Calif Med"},{"key":"2025092008215235200_ref4","doi-asserted-by":"publisher","first-page":"526","DOI":"10.5858\/2000-124-0526-MTTTS","article-title":"Metastatic tumors to the spleen: a 25-year clinicopathologic study","volume":"124","author":"Lam","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"2025092008215235200_ref5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1699-0463.1974.tb00379.x","article-title":"Splenic metastases: frequencies and patterns","volume":"82A","author":"Berge","year":"1974","journal-title":"Acta Pathol Microbiol Scand"},{"key":"2025092008215235200_ref6","first-page":"227","article-title":"Single asymptomatic splenic metastasis of breast carcinoma","volume":"22","author":"Barreca","year":"2001","journal-title":"G Chir"},{"key":"2025092008215235200_ref7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1136\/pmj.78.917.173","article-title":"Isolated splenic metastasis from carcinoma of the breast","volume":"78","author":"Iype","year":"2002","journal-title":"Postgrad Med J"},{"key":"2025092008215235200_ref8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1524-4741.2009.00808.x","article-title":"A diagnostic mishap: solitary splenic carcinomatous metastases from the breast","volume":"15","author":"Iga","year":"2009","journal-title":"Breast J"},{"key":"2025092008215235200_ref9","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/dc.22860","article-title":"Isolated splenic metastasis from carcinoma of the breast","volume":"41","author":"Sufficool","year":"2013","journal-title":"Diagn Cytopathol"},{"key":"2025092008215235200_ref10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3919\/jjsa.75.40","article-title":"A case of splenic metastasis after breast cancer surgery","volume":"75","author":"Hironaka","year":"2014","journal-title":"J Jpn Surg Assoc"},{"key":"2025092008215235200_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.957490","article-title":"Solitary splenic metastasis occurring 19 months after treatment for occult breast cancer","volume":"12","author":"Chen","year":"2022","journal-title":"Front Oncol"},{"key":"2025092008215235200_ref12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4103\/SIJM.SIJM_4_24","article-title":"Isolated distant splenic metastasis in a newly diagnosed case of breast carcinoma detected on 18F-fludeoxyglucose-18 positron emission tomography\/computed tomography","volume":"1","author":"Dang","year":"2025","journal-title":"Sarvodaya Int J Med"},{"key":"2025092008215235200_ref13","doi-asserted-by":"publisher","first-page":"e230453","DOI":"10.1148\/radiol.230453","article-title":"A multicenter study of needle size and safety for splenic biopsy","volume":"310","author":"Kavandi","year":"2024","journal-title":"Radiology"},{"key":"2025092008215235200_ref14","doi-asserted-by":"publisher","first-page":"17588359231161412","DOI":"10.1177\/17588359231161412","article-title":"Oligometastatic breast cancer and metastasis-directed treatment: an aggressive multimodal approach to reach the cure","volume":"15","author":"Merloni","year":"2023","journal-title":"Ther Adv Med Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf751\/64332423\/rjaf751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf751\/64332423\/rjaf751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:21:57Z","timestamp":1758370917000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf751\/8259716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf751","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"rjaf751"}}