{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:16:13Z","timestamp":1758759373897,"version":"3.44.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant triton tumors (MTTs) are a rare subtype of malignant peripheral nerve sheath tumors characterized by rhabdomyoblastic differentiation, often associated with neurofibromatosis type 1 (NF-1). Primary MTTs of the bladder are exceptionally uncommon, with few documented cases. We report a case of a 75-year-old male without neurofibromatosis type 1 history presenting with hematuria and urinary obstruction. Imaging revealed a 6.5\u2009\u00d7\u20094\u2009\u00d7\u20092\u00a0cm invasive bladder mass, and histopathology confirmed a high-grade spindle cell neoplasm with biphasic neurogenic (S100-positive) and rhabdomyoblastic (desmin- and myogenin-positive) differentiation, consistent with a diagnosis of MTT. Despite radical cystoprostatectomy, the patient succumbed to postoperative complications. This case highlights the aggressive behavior, diagnostic challenges, and poor prognosis of bladder MTTs, emphasizing the critical role of immunohistochemistry in distinguishing them from other spindle cell neoplasms. The rarity of this presentation underscores the need for further research to elucidate its pathogenesis and optimize therapeutic strategies.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf756","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:58:20Z","timestamp":1758725900000},"source":"Crossref","is-referenced-by-count":0,"title":["Malignant triton tumor of the bladder with fatal outcome: a rare case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"El Mehdi","family":"Bouayad","sequence":"first","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4205-8051","authenticated-orcid":false,"given":"Taha Yassine","family":"Aaboudech","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-1346","authenticated-orcid":false,"given":"Sabrine","family":"Derqaoui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Bouayad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Department of Radiology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siham","family":"Mesmoudi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoutar","family":"Znati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Abderrahim Bouabid Avenue, Rabat ,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy, Mohammed 5 University , Abderrahim Bouabid Avenue, Rabat 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,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"2025092410581707100_ref1","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.asjsur.2022.06.030","article-title":"Malignant triton tumor of the retroperitoneum in a male unaffected by neurofibromatosis 1: a case report and literature review","volume":"45","author":"Liu","year":"2022","journal-title":"Asian J Surg"},{"key":"2025092410581707100_ref2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12957-020-02036-x","article-title":"Prognosis and risk factors for malignant peripheral nerve sheath tumor: a systematic review and meta-analysis","volume":"18","author":"Cai","year":"2020","journal-title":"World J Surg Oncol"},{"key":"2025092410581707100_ref3","doi-asserted-by":"publisher","first-page":"e16797","DOI":"10.1097\/MD.0000000000016797","article-title":"A series of 10 malignant triton 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