{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T18:10:10Z","timestamp":1759083010981,"version":"3.44.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Noninvasive fungal rhinosinusitis is the most common type of fungal sinusitis, but it rarely leads to orbital apex syndrome. In this case study, we present a 44-year-old female who developed headache and sudden loss of vision in the left eye. Examination revealed ptosis, complete visual loss, and total ophthalmoplegia in the left eye. Imaging showed a fully opacified mass in the left orbital apex and spheno-ethmoidal recess, involving the adjacent ophthalmic artery, optic nerve, and extraocular muscles. The patient was diagnosed with orbital apex syndrome secondary to noninvasive fungal rhinosinusitis. She received a 3-day course of methylprednisolone without improvement, followed by functional endoscopic sinus surgery. Histopathology confirmed a fungal ball (aspergilloma) without tissue invasion. The patient was hospitalized for 2 weeks, treated with perioperative antibiotics, but did not receive systemic antifungal therapy. At 3 months follow-up, headache, proptosis, and pain had resolved, but vision loss and ptosis did not improve significantly. Early recognition and timely surgical intervention are crucial in preventing irreversible complications of noninvasive fungal rhinosinusitis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf766","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T17:37:52Z","timestamp":1759081072000},"source":"Crossref","is-referenced-by-count":0,"title":["Orbital apex syndrome in noninvasive fungal rhinosinusitis: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0457-5045","authenticated-orcid":false,"given":"Zhongju","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Southwest Medical University , No. 25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province 646000 ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-5695","authenticated-orcid":false,"given":"Xiaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, School of Basic Medicine, Southwest Medical University , No. 25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province 646000 ,","place":["PR China"]},{"name":"Public Center of Experimental Technology of Pathogen Biology Technology Platform, Southwest Medical University , No. 25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province 646000 ,","place":["PR of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-6787","authenticated-orcid":false,"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Deyang People's Hospital , No. 173, Section 1, Taishan North Road, Jingyang District, Deyang City, Sichuan Province 618000,","place":["PR of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-4479","authenticated-orcid":false,"given":"Liang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Southwest Medical University , No. 25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province 646000 ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"2025092813374837300_ref1","doi-asserted-by":"publisher","first-page":"e15041","DOI":"10.1097\/md.0000000000015041","article-title":"Cavernous sinus-orbital apex aspergillus infection in a diabetic patient: a case report","volume":"98","author":"Huang","year":"2019","journal-title":"Medicine"},{"key":"2025092813374837300_ref2","doi-asserted-by":"publisher","first-page":"e788","DOI":"10.1097\/scs.0000000000009678","article-title":"Orbital apex syndrome caused by intraorbital aspergillus infection","volume":"34","author":"Lu","year":"2023","journal-title":"J Craniofac Surg"},{"key":"2025092813374837300_ref3","doi-asserted-by":"publisher","first-page":"275340302311767","DOI":"10.1177\/27534030231176774","article-title":"Loss of vision outcome for allergic fungal sinusitis: case report and literature review","volume":"14","author":"Alhussien","year":"2023","journal-title":"Therapeutic Adv Allergy Rhinol"},{"key":"2025092813374837300_ref4","doi-asserted-by":"publisher","first-page":"e39555","DOI":"10.7759\/cureus.39555","article-title":"Orbital complications of extensive allergic fungal rhinosinusitis: a case report","volume":"15","author":"Alharbi","year":"2023","journal-title":"Cureus"},{"key":"2025092813374837300_ref5","first-page":"34","article-title":"CT imaging characteristics and clinical diagnosis of fungal sinusitis [in Chinese]","volume":"2","author":"Guo","year":"2018","journal-title":"Imaging Res Med Appl"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf766\/64420128\/rjaf766.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf766\/64420128\/rjaf766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T17:37:53Z","timestamp":1759081073000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf766\/8267034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf766","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"rjaf766"}}