{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:11:39Z","timestamp":1759331499893,"version":"build-2065373602"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This report presents a case of a Glioma-associated homologue-1 (GLI1)-altered mesenchymal tumour with novel gene fusion arising from the pleura in a 25-year-old female undergoing treatment for primary colorectal adenocarcinoma. A pleural nodule was incidentally detected during staging, and biopsy revealed a mesenchymal tumour with a novel NCOR2(exon 7)::GLI1(exon 6) gene fusion. The tumour showed an indolent course over 10\u00a0months of surveillance during chemotherapy, with no significant growth. Despite the absence of malignant features, such as high mitotic rate, necrosis, or large size, and a low proliferation index, surgical excision was chosen due to the rarity and uncertain prognosis of this fusion. Histology confirmed a low-grade tumour with unusual SOX10 expression. This case expands the understanding of GLI1-altered mesenchymal tumours, especially in uncommon sites like the pleura, and highlights the importance of multidisciplinary decision-making. Ongoing molecular and pathological analysis is critical to establish robust diagnostic and prognostic frameworks for such rare tumour entities.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf781","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:38:54Z","timestamp":1759235934000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of GLI1-altered mesenchymal pleural tumour with novel gene fusion: a clinical perspective"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-8441","authenticated-orcid":false,"given":"Sheikh Izzat Bin Zainal-Abidin","family":"Bahajjaj","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery , Singapore General Hospital, 5 Hospital Drive, Singapore 169609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia Ming Li","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery , Singapore General Hospital, 5 Hospital Drive, Singapore 169609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Livingston","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology , Singapore General Hospital, 20 College Road, Singapore 169856"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"2025093008374716500_ref1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.path.2023.06.004","article-title":"GLI1-altered mesenchymal tumors","volume":"17","author":"Cloutier","year":"2024","journal-title":"Surg Pathol Clin"},{"key":"2025093008374716500_ref2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/jclinpath-2020-206431","article-title":"Gene of the month: GLI-1","volume":"73","author":"Chetty","year":"2020","journal-title":"J Clin Pathol"},{"key":"2025093008374716500_ref3","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s00428-021-03224-0","article-title":"GLI1-altered mesenchymal tumor: a clinicopathological and molecular analysis of ten additional cases of an emerging entity","volume":"480","author":"Liu","year":"2022","journal-title":"Virchows Arch"},{"key":"2025093008374716500_ref4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/PAS.0000000000001439","article-title":"Head and neck mesenchymal neoplasms with GLI1 gene alterations: a pathologic entity with distinct histologic features and potential for distant metastasis","volume":"44","author":"Xu","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"2025093008374716500_ref5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.rmed.2015.05.014","article-title":"Pleural neoplastic pathology","volume":"109","author":"Karpathiou","year":"2015","journal-title":"Respir Med"},{"key":"2025093008374716500_ref6","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s12105-021-01388-4","article-title":"Epithelioid soft tissue neoplasm of the soft palate with a PTCH1-GLI1 fusion: a case report and review of the literature","volume":"16","author":"Klub\u00ed\u010dkov\u00e1","year":"2022","journal-title":"Head Neck Pathol"},{"key":"2025093008374716500_ref7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pathol.2020.07.013","article-title":"GLI activated epithelioid cell tumour: report of a case and proposed new terminology","volume":"53","author":"Aivazian","year":"2021","journal-title":"Pathology"},{"key":"2025093008374716500_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100635","article-title":"GLI1-altered mesenchymal tumor-multiomic characterization of a case series and patient-level meta-analysis of one hundred sixty-seven cases for risk stratification","volume":"38","author":"Yeung","year":"2025","journal-title":"Mod Pathol"},{"key":"2025093008374716500_ref9","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1097\/PAS.0000000000002272","article-title":"A comprehensive clinicopathologic and molecular reappraisal of GLI1-altered mesenchymal tumors with pooled outcome analysis showing poor survival in GLI1 - amplified versus GLI1-rearranged tumors","volume":"48","author":"Saoud","year":"2024","journal-title":"Am J Surg Pathol"},{"key":"2025093008374716500_ref10","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1200\/JCO.2004.11.069","article-title":"XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer","volume":"22","author":"Cassidy","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf781\/64441410\/rjaf781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/9\/rjaf781\/64441410\/rjaf781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:38:54Z","timestamp":1759235934000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf781\/8268770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf781","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"rjaf781"}}