{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:12:17Z","timestamp":1759518737270,"version":"build-2065373602"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymphoepithelioma-like carcinoma (LELC) of the urethra is an exceptionally rare and aggressive neoplasm, with limited evidence available to inform optimal management. We present the case of a 63-year-old male diagnosed with high-grade urethral LELC, who presented with locally advanced disease. The patient underwent partial penectomy with bilateral inguinal lymphadenectomy, followed by systemic chemotherapy and immunotherapy. This case underscores the importance of a multidisciplinary approach combining surgical resection with systemic therapy in the management of aggressive urethral malignancies. Given the paucity of literature on urethral LELC, additional case reports are critical to enhance our understanding and to develop evidence-based treatment strategies for this rare entity.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf785","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:48:35Z","timestamp":1759517315000},"source":"Crossref","is-referenced-by-count":0,"title":["Lymphoepithelioma-like carcinoma of the distal urethra: a case report and management strategies"],"prefix":"10.1093","volume":"2025","author":[{"given":"Ramiro","family":"Fonseca","sequence":"first","affiliation":[{"name":"Department of Urology, Instituto M\u00e9dico Tecnol\u00f3gico , Carrer Escorial 171, Barcelona 08024 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ignacio Perez","family":"Reggeti","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario Bellvitge , Carrer de la Feixa Llarga s\/n, Barcelona 08907 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ferreiro Pareja","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario Bellvitge , Carrer de la Feixa Llarga s\/n, Barcelona 08907 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Paganini","sequence":"additional","affiliation":[{"name":"Department of Urology, Instituto M\u00e9dico Tecnol\u00f3gico , Carrer Escorial 171, Barcelona 08024 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcial","family":"Berrios-Quinteros","sequence":"additional","affiliation":[{"name":"Department of Urology, Instituto M\u00e9dico Tecnol\u00f3gico , Carrer Escorial 171, Barcelona 08024 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Eduardo","family":"Chechile","sequence":"additional","affiliation":[{"name":"Department of Urology, Instituto M\u00e9dico Tecnol\u00f3gico , Carrer Escorial 171, Barcelona 08024 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-5543","authenticated-orcid":false,"given":"Nahuel","family":"Paesano","sequence":"additional","affiliation":[{"name":"Department of Urology, Instituto M\u00e9dico Tecnol\u00f3gico , Carrer Escorial 171, Barcelona 08024 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"2025100314483329700_ref1","first-page":"469","article-title":"EUA guidelines on primary urethral carcinoma\u20142020 update","volume":"3","author":"Gakis","year":"2020","journal-title":"Eur Urol Oncol"},{"key":"2025100314483329700_ref2","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/S0090-4295(98)00659-1","article-title":"Male urethral carcinoma: analysis of treatment outcome","volume":"53","author":"Dalbagni","year":"1999","journal-title":"Urology"},{"key":"2025100314483329700_ref3","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/00000478-199405000-00005","article-title":"Lymphoepithelioma-like carcinoma of the urinary bladder","volume":"18","author":"Amin","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"2025100314483329700_ref4","first-page":"8","article-title":"Molecular diagnosis of Epstein-Barr virus in paraffin-embedded tissues of tumors with abundant lymphoid infiltration","volume":"50","author":"Korabecn\u00e1","year":"2003","journal-title":"Neoplasma"},{"key":"2025100314483329700_ref5","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/PAS.0b013e31820f709e","article-title":"Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features","volume":"35","author":"Williamson","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"2025100314483329700_ref6","doi-asserted-by":"publisher","first-page":"771","DOI":"10.12998\/wjcc.v8.i4.771","article-title":"Lymphoepithelioma-like carcinoma of the upper urinary tract: a systematic review of case reports","volume":"8","author":"Lai","year":"2020","journal-title":"World J Clin Cases"},{"key":"2025100314483329700_ref7","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/00000478-199106000-00005","article-title":"Carcinomas of the urinary bladder simulating malignant lymphoma. A report of five cases","volume":"15","author":"Zukerberg","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"2025100314483329700_ref8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/modpathol.3800823","article-title":"Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases","volume":"20","author":"Tamas","year":"2007","journal-title":"Mod Pathol"},{"key":"2025100314483329700_ref9","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1186\/1756-0500-7-779","article-title":"Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature","volume":"7","author":"Yoshino","year":"2014","journal-title":"BMC Res Notes"},{"key":"2025100314483329700_ref10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1464-410X.2007.06901.x","article-title":"Penile-preserving surgery for male distal urethral carcinoma","volume":"100","author":"Smith","year":"2007","journal-title":"BJU Int"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf785\/64488564\/rjaf785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf785\/64488564\/rjaf785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:48:36Z","timestamp":1759517316000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf785\/8272851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf785","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]},"article-number":"rjaf785"}}