{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:53:16Z","timestamp":1759452796169,"version":"build-2065373602"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The causality of thymoma (TM) or thymic hyperplasia and various autoimmune diseases (AISs) remains poorly understood. To date, there have been no confirmed cases of pathologically complete regression of TM. We present a rare case of complete regression of an anterior mediastinal tumour secondary to the removal of metallic dental crowns as a treatment for metal allergy assessed to exacerbate pityriasis rubra pilaris, a rare cutaneous disease. After dental crown removal, the skin lesions improved, and the anterior mediastinal nodule (AMN) shrank rapidly through transient enlargement with a low density in the central area. Despite observation being an option, the patient preferred surgical resection and pathological examination, which revealed no remnant neoplasm. Treatment for skin conditions rarely induces complete regression of the AMN. This case highlights the potential novel link between anterior mediastinal tumours and AISs, including cutaneous disorders, and raises awareness amongst clinicians of this possible association.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf786","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:17:37Z","timestamp":1759429057000},"source":"Crossref","is-referenced-by-count":0,"title":["Regressed anterior mediastinal nodule secondary to removal of dental crowns"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-0439","authenticated-orcid":false,"given":"Masashi","family":"Nagata","sequence":"first","affiliation":[{"name":"Department of General Surgery, Okinawa Kyodo Hospital , 4-10-55, Kohagura, Naha, Okinawa 900-8558 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Okinawa Red Cross Hospital , 1-3-1 Yogi, Naha, Okinawa 902-8588 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Jichi Medical University , 3311-1 Yakushiji, Shimotuke, Tochigi 329-0498 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Jichi Medical University , 3311-1 Yakushiji, Shimotuke, Tochigi 329-0498 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Tsubochi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Jichi Medical University , 3311-1 Yakushiji, Shimotuke, Tochigi 329-0498 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Jichi Medical University Saitama Medical Center ,","place":["1-847 Amanuma, Omiya, Saitama City, Saitama 330-8503, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"2025100214173165800_ref1","doi-asserted-by":"publisher","first-page":"7571","DOI":"10.21037\/jtd-2019-thym-10","article-title":"Autoimmune disorders and paraneoplastic syndromes in thymoma","volume":"12","author":"Blum","year":"2020","journal-title":"J Thorac Dis"},{"key":"2025100214173165800_ref2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.lungcan.2022.02.004","article-title":"Clinical practices for non-neoplastic thymic lesions: results from a multidisciplinary cohort","volume":"166","author":"Joubert","year":"2022","journal-title":"Lung Cancer"},{"key":"2025100214173165800_ref3","first-page":"e240125","article-title":"Multi-disciplinary collaboration in diagnosing thymic hyperplasia in a Graves\u2019 disease patient","volume":"2025","author":"Kyaw","year":"2025","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2025100214173165800_ref4","doi-asserted-by":"publisher","first-page":"luad083","DOI":"10.1210\/jcemcr\/luad083","article-title":"Thymic hyperplasia and graves disease: a nonincidental association","volume":"1","author":"Pla Peris","year":"2023","journal-title":"JCEM Case Rep"},{"key":"2025100214173165800_ref5","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/1759-7714.14407","article-title":"Thymoma exhibiting spontaneous regression with developing myasthenia gravis: a case report","volume":"13","author":"Nishina","year":"2022","journal-title":"Thorac Cancer"},{"key":"2025100214173165800_ref6","doi-asserted-by":"publisher","first-page":"584703","DOI":"10.3389\/fimmu.2021.584703","article-title":"Remission of thymoma on steroid therapy in a patient with atypical thymoma-associated multiorgan autoimmunity: a case report and literature review","volume":"12","author":"Wrona","year":"2021","journal-title":"Front Immunol"},{"key":"2025100214173165800_ref7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.arbres.2022.07.005","article-title":"Partial regression of thymoma with the treatment of myasthenia gravis","volume":"59","author":"Aydin","year":"2023","journal-title":"Arch Bronconeumol"},{"key":"2025100214173165800_ref8","doi-asserted-by":"publisher","first-page":"14901","DOI":"10.1007\/s00432-023-05263-3","article-title":"Development and validation of a contrast-enhanced CT-based radiomics nomogram for differentiating mass-like thymic hyperplasia and low-risk thymoma","volume":"149","author":"Dong","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"2025100214173165800_ref9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s40291-024-00767-1","article-title":"The role of [18F]F-FDG PET\/CT for predicting histology and prognosis in patients with thymic lesions","volume":"29","author":"Pizzuto","year":"2025","journal-title":"Mol Diagn Ther"},{"key":"2025100214173165800_ref10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/his.15088","article-title":"Benign lesions of the mediastinum","volume":"84","author":"Gerber","year":"2024","journal-title":"Histopathology"},{"key":"2025100214173165800_ref11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.21037\/gs.2019.12.18","article-title":"Thymic lymphoid hyperplasia with Graves' disease in a 28-year-old female: a case report","volume":"9","author":"Zhang","year":"2020","journal-title":"Gland Surg"},{"key":"2025100214173165800_ref12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s40257-023-00836-x","article-title":"Pityriasis rubra pilaris: an updated review of clinical presentation, etiopathogenesis, and treatment options","volume":"25","author":"Joshi","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"2025100214173165800_ref13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.12703\/r\/10-62","article-title":"Recent advances in palmoplantar pustulosis","volume":"10","author":"Brunasso","year":"2021","journal-title":"Fac Rev"},{"key":"2025100214173165800_ref14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s40792-022-01510-w","article-title":"A spontaneous reduction in tumor size of a thymic carcinoma: a case report","volume":"8","author":"Kuroki","year":"2022","journal-title":"Surg Case Rep"},{"key":"2025100214173165800_ref15","doi-asserted-by":"publisher","first-page":"1218517","DOI":"10.3389\/fonc.2023.1218517","article-title":"Case report: paraneoplastic psoriasis in thymic carcinoma. Front","volume":"13","author":"Mix","year":"2023","journal-title":"Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf786\/64473014\/rjaf786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf786\/64473014\/rjaf786.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:17:38Z","timestamp":1759429058000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf786\/8271054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf786","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]},"article-number":"rjaf786"}}