{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:47:38Z","timestamp":1763142458636,"version":"build-2065373602"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute mesenteric venous thrombosis is a rare and potentially lethal cause of intestinal ischemia. We report a 38-year-old woman with abnormal uterine bleeding, with anemia, and prolonged use of medroxyprogesterone acetate. She presented severe abdominal pain, peritoneal signs, and systemic inflammatory response. Computed tomography revealed thrombosis of the portal, splenic, and superior mesenteric veins with jejunal wall thickening. Initial laparotomy showed a viable bowel; full anticoagulation was started. She later developed perforation requiring jejunal resection and subsequent reoperation for anastomotic dehiscence. Extensive workup revealed no prothrombotic disorder other than progestin use. This case highlights the need to consider hormonal agents as potential triggers of porto-spleno-mesenteric thrombosis, even in young women without comorbidities, and to pursue multidisciplinary, individualized management to balance timely surgery with preservation of bowel length.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf791","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:30:31Z","timestamp":1759771831000},"source":"Crossref","is-referenced-by-count":1,"title":["Porto-spleno-mesenteric thrombosis secondary to medroxyprogesterone acetate as a treatment for abnormal uterine bleeding: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"David J","family":"Alvarez Chavez","sequence":"first","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A","family":"Maciel Urzua","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C","family":"Torres Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A","family":"Bautista L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3317-0768","authenticated-orcid":false,"given":"Carla M","family":"Cruz Rocha","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A","family":"Casado De La Torre","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela I","family":"S\u00e1nchez Lozano","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Universidad de Guadalajara, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca ,\u201d Calle Salvador Quevedo y Zubieta, 750, 44360 Guadalajara, Jalisco,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2025100613302579500_ref1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13017-022-00443-x","article-title":"Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery","volume":"17","author":"Bala","year":"2022","journal-title":"World J Emerg Surg"},{"key":"2025100613302579500_ref2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.22201\/facmed.24486798e.2023.66.6.246","article-title":"Trombosis venosa mesent\u00e9rica y portal como causa infrecuente de obstrucci\u00f3n e isquemia intestinal en paciente joven","volume":"66","author":"Aguilar Jaramillo","year":"2023","journal-title":"Reporte de caso Rev Fac Med (Mex)"},{"key":"2025100613302579500_ref3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.medin.2015.08.006","article-title":"Trombosis venosa portal, mesent\u00e9rica y espl\u00e9nica aguda idiop\u00e1tica: tratamiento fibrinol\u00edtico locorregional","volume":"40","author":"Andreu-Ruiz","year":"2016","journal-title":"Med Intensiva"},{"key":"2025100613302579500_ref4","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3390\/jcm13051217","article-title":"Revascularization strategies for acute and chronic mesenteric ischemia: a narrative review","volume":"13","author":"Gries","year":"2024","journal-title":"J Clin Med"},{"key":"2025100613302579500_ref5","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s00068-023-02349-y","article-title":"Acute mesenteric ischemia: diagnostic and therapeutic challenges","volume":"49","author":"Demetriades","year":"2023","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2025100613302579500_ref6","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1007\/s00068-023-02281-1","article-title":"Factors associated with the need for long-term total parenteral nutrition in survivors of acute superior mesenteric artery occlusion","volume":"49","author":"Nakao","year":"2023","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2025100613302579500_ref7","doi-asserted-by":"publisher","first-page":"e4944","DOI":"10.1136\/bmj.e4944","article-title":"Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis","volume":"345","author":"Mantha","year":"2012","journal-title":"BMJ"},{"key":"2025100613302579500_ref8","doi-asserted-by":"publisher","first-page":"e33880","DOI":"10.7759\/cureus.33880","article-title":"A rare case of splenic artery thrombosis provoked by medroxyprogesterone acetate requiring splenectomy","volume":"15","author":"Haider","year":"2023","journal-title":"Cureus"},{"key":"2025100613302579500_ref9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/AOG.0000000000004892","article-title":"Association of progestogens and venous thromboembolism among women of reproductive age","volume":"140","author":"Cockrum","year":"2022","journal-title":"Obstet Gynecol"},{"key":"2025100613302579500_ref10","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s00068-022-01924-z","article-title":"Outcome of laparotomy and conservative treatment of patients with acute mesenteric venous ischemia with viable bowel","volume":"49","author":"Emile","year":"2023","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2025100613302579500_ref11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/biomedicines12010085","article-title":"The impact of biomarkers on the early detection of acute mesenteric ischemia","volume":"12","author":"Zafirovski","year":"2024","journal-title":"Biomedicines"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf791\/64521711\/rjaf791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf791\/64521711\/rjaf791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:30:32Z","timestamp":1759771832000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf791\/8276084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf791","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]},"article-number":"rjaf791"}}