{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:23:34Z","timestamp":1781519014990,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Brown tumor, also known as osteitis fibrosa cystica, is a benign bone lesion due to excessive lytic action by osteoclasts, in the presence of primary, secondary, or tertiary hyperparathyroidism. Due to early screening, they are a rare occurrence. This report presents a case of a 47-year-old man on regular hemodialysis presenting with compressive thoracic myelopathy. Based on elevated parathyroid hormone, imaging, and histopathology, the diagnosis of brown tumor was confirmed. He then underwent tumor excision, following which the underlying secondary hyperparathyroidism was treated with calcitriol and calcium replacement. Though secondary hyperparathyroidism is a common complication of chronic kidney disease, brown tumors are a rare manifestation and uncommonly located in the spine. Differential diagnoses include metastatic lesions, plasmacytomas, giant cell granulomas, or simple bone cysts. Early diagnosis and management of a spinal brown tumor can prevent neurological complications.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf821","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:09:06Z","timestamp":1760699346000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple spinal brown tumors presenting as compressive thoracic myelopathy in a patient on maintenance hemodialysis"],"prefix":"10.1093","volume":"2025","author":[{"given":"Sharvari","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Medicine, Kasturba Medical College , Tiger Circle Road, Madhav Nagar, Manipal 576104 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra A","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College , Tiger Circle Road, Madhav Nagar, Manipal 576104 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu R","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College , Tiger Circle Road, Madhav Nagar, Manipal 576104 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"2025101707090159300_ref1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4103\/isj.isj_48_20","article-title":"Brown tumor causing thoracic compressive myelopathy: a case report and review of literature","volume":"4","author":"Ramachandraiah","year":"2021","journal-title":"Indian Spine J"},{"key":"2025101707090159300_ref2","doi-asserted-by":"publisher","first-page":"e05376","DOI":"10.1002\/ccr3.5376","article-title":"Hyperparathyroidism: unusual location of brown tumors","volume":"10","author":"Fazaa","year":"2022","journal-title":"Clin Case Rep"},{"key":"2025101707090159300_ref3","doi-asserted-by":"publisher","first-page":"e2024S132","DOI":"10.1590\/1806-9282.2024S132","article-title":"Update on brown tumor of hyperparathyroidism","volume":"70","author":"Guedes","year":"2024","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"2025101707090159300_ref4","first-page":"423","article-title":"The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification","volume":"74","author":"London","year":"2010","journal-title":"Clin Nephrol"},{"key":"2025101707090159300_ref5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1001\/archsurg.142.4.381","article-title":"Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas","volume":"142","author":"Stephen","year":"2007","journal-title":"Arch Surg"},{"key":"2025101707090159300_ref6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.5414\/CNCS110195","article-title":"Brown tumor complicating end-stage kidney disease","volume":"2020","author":"Wiederkehr","year":"2020","journal-title":"Clin Nephrol Case Stud"},{"key":"2025101707090159300_ref7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.7861\/clinmedicine.14-5-542","article-title":"Metastatic spinal cord compression: a rare but important complication of cancer","volume":"14","author":"Robson","year":"2014","journal-title":"Clin Med (Lond)"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf821\/64730143\/rjaf821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf821\/64730143\/rjaf821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:09:07Z","timestamp":1760699347000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf821\/8290469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf821","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]},"article-number":"rjaf821"}}