{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:35:12Z","timestamp":1761226512670,"version":"build-2065373602"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surgical site infection (SSI) remains a major concern after ileostomy closure, limiting the adoption of primary closure despite the cosmetic and practical advantages of primary closure. A 0.1% betaine\u20130.1% polyhexanide solution, a surfactant\u2013disinfectant solution with biofilm-disrupting properties, has been shown to significantly reduce SSI rates in various acute and chronic wounds throughout the body. This single-institution case series is the first in the literature to evaluate SSI rates with the use of betaine\u2013polyhexanide irrigation and primary closure of ileostomy sites. All patients demonstrated well-healed incisions without SSI, wound dehiscence, or other wound-related complications at their follow-up visits 10\u201348\u00a0days post-operatively. Compared to the historically high SSI rates with ileostomy site primary closure, this study\u2019s findings suggest that betaine\u2013polyhexanide irrigation may allow for safe primary closure while preserving its advantages of reduced wound care burden and improved cosmesis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf846","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:28:30Z","timestamp":1759750110000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary closure of ileostomy site after irrigation with betaine\u2013polyhexanide: a case series"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1960-9579","authenticated-orcid":false,"given":"Henry","family":"Krasner","sequence":"first","affiliation":[{"name":"Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas , 625 Shadow Ln, Las Vegas, NV 89106 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail W","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas , 1707 W Charleston Blvd, Las Vegas, NV 89102 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Horner","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas , 1707 W Charleston Blvd, Las Vegas, NV 89102 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovunc","family":"Bardakcioglu","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas , 1707 W Charleston Blvd, Las Vegas, NV 89102 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2025102309122864300_ref1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3393\/ac.2016.32.4.144","article-title":"Purse-string versus linear conventional skin wound closure of an ileostomy: a randomized clinical trial","volume":"32","author":"Alvandipour","year":"2016","journal-title":"Ann Coloproctol"},{"key":"2025102309122864300_ref2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3393\/jksc.2011.27.2.58","article-title":"Conventional linear versus purse-string skin closure after loop ileostomy reversal: comparison of wound infection rates and operative outcomes","volume":"27","author":"Lee","year":"2011","journal-title":"J Korean Soc Coloproctol"},{"key":"2025102309122864300_ref3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s00384-018-3139-y","article-title":"Purse-string skin closure versus linear skin closure techniques in stoma closure: a comprehensive meta-analysis with trial sequential analysis of randomised trials","volume":"33","author":"Hajibandeh","year":"2018","journal-title":"Int J Colorectal Dis"},{"key":"2025102309122864300_ref4","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/bjs.7151","article-title":"Randomized clinical trial of short-term outcomes following purse-string versus conventional closure of ileostomy wounds","volume":"97","author":"Reid","year":"2010","journal-title":"Br J Surg"},{"key":"2025102309122864300_ref5","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/DCR.0000000000000401","article-title":"Pursestring closure versus conventional primary closure following stoma reversal to reduce surgical site infection rate: a meta-analysis of randomized controlled trials","volume":"58","author":"Hsieh","year":"2015","journal-title":"Dis Colon Rectum"},{"key":"2025102309122864300_ref6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00423-024-03332-w","article-title":"Comparison of purse-string technique vs linear suture for skin closure after ileostomy reversal. A randomized controlled trial","volume":"409","author":"Carannante","year":"2024","journal-title":"Langenbecks Arch Surg"},{"key":"2025102309122864300_ref7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5662\/wjm.v11.i4.222","article-title":"Wound irrigation for preventing surgical site infections","volume":"11","author":"Papadakis","year":"2021","journal-title":"World J Methodol"},{"key":"2025102309122864300_ref8","first-page":"CD012234","article-title":"Intracavity lavage and wound irrigation for prevention of surgical site infection","volume":"10","author":"Norman","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2025102309122864300_ref9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1089\/sur.2018.061","article-title":"Does wound irrigation with chlorhexidine gluconate reduce the surgical site infection rate in closure of temporary loop ileostomy? A prospective clinical study","volume":"19","author":"Goztok","year":"2018","journal-title":"Surg Infect"},{"key":"2025102309122864300_ref10","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.12968\/bjon.2006.15.22.22559","article-title":"Prontosan wound irrigation and gel: management of chronic wounds","volume":"15","author":"Horrocks","year":"2006","journal-title":"Br J Nurs"},{"key":"2025102309122864300_ref11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/jsxmed\/qdad055","article-title":"Dipping titan implants in irrisept solution (0.05% chlorhexidine gluconate) and exposure to various aerobic, anaerobic, and fungal species","volume":"20","author":"Karpman","year":"2023","journal-title":"J Sex Med"},{"key":"2025102309122864300_ref12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1089\/sur.2019.053","article-title":"Wound irrigation with chlorhexidine gluconate reduces surgical site infection in pilonidal disease: single-blind prospective study","volume":"21","author":"Arslan","year":"2020","journal-title":"Surg Infect (Larchmt)"},{"key":"2025102309122864300_ref13","first-page":"113","article-title":"Chlorhexidine gluconate, its properties and applications in endodontics","volume":"2","author":"Mohammadi","year":"2008","journal-title":"Iran Endod J"},{"key":"2025102309122864300_ref14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/01.GOX.0000842800.77716.3f","article-title":"The efficacy of breast implant irrigant solutions against gram-negative infections: an in vitro model","volume":"10","author":"Ha","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"2025102309122864300_ref15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.eimc.2016.02.008","article-title":"In vitro activity of a polyhexanide\u2013betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens","volume":"35","author":"L\u00f3pez-Rojas","year":"2017","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2025102309122864300_ref16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.12968\/jowc.2016.25.3.160","article-title":"Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT","volume":"25","author":"Bellingeri","year":"2016","journal-title":"J Wound Care"},{"key":"2025102309122864300_ref17","article-title":"Novel intra- operative wound irrigation solution to manage infection prevention in patients undergoing primary joint arthroplasty: retrospective review of a case series of 308 patients","volume":"4","author":"Jacob","year":"2023","journal-title":"J Orthop Exp"},{"key":"2025102309122864300_ref18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/1534734617690949","article-title":"Randomized controlled trial of polyhexanide\/betaine gel versus silver sulfadiazine for partial-thickness burn treatment","volume":"16","author":"Wattanaploy","year":"2017","journal-title":"Int J Low Extrem Wounds"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf846\/64881723\/rjaf846.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/10\/rjaf846\/64881723\/rjaf846.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:12:35Z","timestamp":1761225155000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf846\/8300192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf846","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]},"article-number":"rjaf846"}}