{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:38:45Z","timestamp":1761316725823,"version":"build-2065373602"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present a unique case of a 61-year-old female with achondroplasia and end-stage osteoarthritis of both knees who presented with severe pain and bilateral varus deformities of over 40 degrees. The patient underwent single-stage bilateral total knee arthroplasty (TKA) using cemented rotating-hinge implants with long stems. At 5-year follow-up, the patient has neutral limb alignment, pain-free ambulation without assistive devices, and stable implants on radiographs. This is one of the first reported cases of simultaneous bilateral TKA in a patient with achondroplasia and extreme bilateral varus deformity, highlighting how successful correction can be achieved using hinged implants and careful surgical planning, underscoring the feasibility of one-stage bilateral intervention in this rare and challenging scenario.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf855","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:04:31Z","timestamp":1760097871000},"source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous bilateral total knee replacement in a patient with achondroplasia and severe varus deformity: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1310-623X","authenticated-orcid":false,"given":"Danil","family":"Chernov","sequence":"first","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences , 955 Main St. Buffalo, NY 14203 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0623-2864","authenticated-orcid":false,"given":"Nicholas","family":"Frappa","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences , 955 Main St. Buffalo, NY 14203 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Listopadzki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Sports Medicine , 462 Grider St. Buffalo, NY 14215 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Alben","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Sports Medicine , 462 Grider St. Buffalo, NY 14215 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Sports Medicine , 462 Grider St. Buffalo, NY 14215 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajkumar","family":"Selvanayagam","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Sports Medicine , 462 Grider St. Buffalo, NY 14215 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridhar R","family":"Rachala","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Sports Medicine , 462 Grider St. Buffalo, NY 14215 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"2025102410324716200_ref1","first-page":"368","article-title":"Achondroplasia is defined by recurrent G380R mutations of FGFR3","volume":"56","author":"Bellus","year":"1995","journal-title":"Am J Hum Genet"},{"key":"2025102410324716200_ref2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1302\/0301-620X.89B1.18223","article-title":"Development of genu varum in achondroplasia: relation to fibular overgrowth","volume":"89","author":"Lee","year":"2007","journal-title":"J Bone Joint Surg Br"},{"key":"2025102410324716200_ref3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11999-010-1516-0","article-title":"Technical challenges of total knee arthroplasty in skeletal dysplasia","volume":"469","author":"Kim","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"2025102410324716200_ref4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s13023-023-02738-x","article-title":"Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers","volume":"18","author":"Nahm","year":"2023","journal-title":"Orphanet J Rare Dis"},{"key":"2025102410324716200_ref5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.artd.2021.08.011","article-title":"Total joint arthroplasty in patients with achondroplasia: comparison of 90-day adverse events and 5-year implant survival","volume":"11","author":"Moore","year":"2021","journal-title":"Arthroplast Today"},{"key":"2025102410324716200_ref6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.artd.2020.12.023","article-title":"Complex primary total knee arthroplasty in a patient with achondroplasia, osteoarthritis, and severe coronal instability","volume":"8","author":"Stancil","year":"2021","journal-title":"Arthroplast Today."},{"key":"2025102410324716200_ref7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.13107\/jocr.2250-0685.738","article-title":"Two-staged bilateral, femoral alignment osteotomy with concomitant total knee arthroplasty in an achondroplasia patient - 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